http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1336443-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0cb7734bc2e5840db630f0ae7c29684 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate | 1970-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1336443-A |
| titleOfInvention | Preparation of ,3,5-nucleotides |
| abstract | 1336443 3<SP>1</SP>,5<SP>1</SP>-Nucleotides; purine derivatives AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE 7 Oct 1970 [10 Oct 1969 2 Oct 1970] 13401/73 Divided out of 1336441 Headings C2P and C2C 3<SP>1</SP>,5<SP>1</SP>-Nucleotides and salts thereof are prepared by cyclizing a 5<SP>1</SP>-nucleotide or salt thereof by reaction with dicyclohexylcarbodiimide in the presence of pyridine and dimethyl formamide. The 3<SP>1</SP>,5<SP>1</SP>-nucleotide may have the Formula I: where one of X and Y is H or alkyl and the other is alkyl and R 1 and R 2 are both H, or X and Y are both H, R 1 is H, Br, SH, OH, SCH 3 or NH 2 and R 2 is H or NH 2 . The starting material 2-aminoadenosine-5<SP>1</SP>- monophosphate is prepared (isolated as its triethylammonium salt) by reacting 2-amino-6- chloro - 9 (2<SP>1</SP>,3<SP>1</SP>,5<SP>1</SP> - triacetyl - beta - D - ribofuranosyl)purine with a saturated solution of ammonia to deacetylate it, reacting the 2- amino-6-chloro nucleoside produced with concentrated ammonia in an autoclave to produce the corresponding 2,6-diamino-nucleoside, reacting this with dimethoxy propane to produce the corresponding 2<SP>1</SP>,3<SP>1</SP>-isopropylidene derivative, and finally phosphorylating this product with phosphorus oxychloride, the isopropylidene groups being eliminated by warming. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023031481-A1 |
| priorityDate | 1969-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.