http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1334296-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f88f84fc279fe5d0b9b5ec3c88c2e2b2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-06 |
| filingDate | 1971-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1334296-A |
| titleOfInvention | 3-aryloxy-8-carbamoylnortropanes |
| abstract | 1334296 3 - Aryloxy - 8 - carbamoylnortropanes A H ROBINS CO Inc 25 Aug 1971 [31 Aug 1970] 39945/71 Heading C2C Novel compounds of the Formula I wherein R<SP>1</SP> and R<SP>2</SP> each represent hydrogen, C 1-8 alkyl or phenyl; R<SP>3</SP> is hydrogen, bromine, chlorine or trifluoromethyl; and X is oxygen or sulphur may be prepared by reaction of a compound II with (a) alkyl or phenyl isocyanates or isothiocyanates; (b) N,N-disubstituted carbamoyl halides and N,N-disubstituted thiocarbamoyl halides, R<SP>1</SP>R<SP>2</SP>NCOY, wherein Y is a halogen or (c) when R<SP>1</SP>=R<SP>2</SP>=H, with nitrourea or nitroisothiourea, NO 2 NHOXNH 2 . The intermediate of the Formula II may be prepared by debenzylation of the appropriate 8-benzyl - 3 - phenoxynortropane either by hydrogenation or when R<SP>3</SP> is bromine or chlorine by reaction with cyanogen bromide to form the 8 - cyano - 3 - phenoxynortropane followed by hydrolysis. The 8 - benzyl - 3 - phenoxynortropane derivatives may be formed by reaction of 8-benzyl nortropine with a strong base followed by the appropriately substituted fluorobenzene. Pharmaceutical compositions of the compounds I show anti-convulsant activity when administered orally with the usual excipients. |
| priorityDate | 1970-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.