http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1332816-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b12c644e81b74a1c2661d3dfb0fe3997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-673 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-31 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-527 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-31 |
| filingDate | 1970-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1332816-A |
| titleOfInvention | Phenylcyclohexane derivatives and methods for their manu facture |
| abstract | 1332816 4-Phenylcyclohexane derivatives MAGGIONI & C-SpA 8 Dee 1970 [13 Dec 1969] 58327/70 Heading C2C Novel compounds of the Formula I wherein X is COCH 2 OH or COCH 3 and R is hydrogen or hydroxyl provided that when X is COCH 3 R is a hydroxyl group may be prepared (a) in the case where X is COCH 2 OH and R is hydrogen by hydrolysis of 4-phenylacetoxyacetylcyclohexane with aqueous alkali metal carbonate; (b) where X is COCH 2 OH and R is hydroxyl by forming the cyanohydrin of 4- phenyl-acetoxyacetylcyclohexane, reacting the cyanhydrin with phosphorus oxychloride and pyridine to yield 1-acetoxy-2-cyano-2-(4-phenylcyclohexylidene)ethane, which is reacted with potassium permanganate in piperidine to form 4-phenyl-1-acetoxyacetylcyclohexanol which is hydrolysed with alkali metal metal carbonate to 4 - phenyl - 1 - hydroxyacetylcyclohexanol; (c) where X is COCH 3 and R is hydroxyl, by forming the bisulphite of 4-phenylcyclohexanone, reacting the bisulphite with alkali metal cyanide to form the 4-phenyl-1-cyano-cyclohexanol, hydrolysing to the 4-phenyl-1-carboxycyclohexanol, which is reacted with methyl lithium to form 4-phenyl-1-acetylcyclohexanol or reacting 4-phenylcyclohexanone with acetylene and sodamide in liquid ammonia and oxidizing the product with mercuric sulphate in sulphuric acid to 4-phenyl-1-acetyl cyclohexanol. Pharmaceutical compositions of the compounds I show anti-inflammatory and progestinic activity. |
| priorityDate | 1969-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 63.