http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1327552-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd5a5908c54e6b4ca24053f2900e626e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-147 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-10 |
| filingDate | 1972-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1327552-A |
| titleOfInvention | 1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparation |
| abstract | 1327552 Benzylpyrimidone derivatives MORTON-NORWICH PRODUCTS Inc 21 March 1972 [25 March 1971] 13248/72 Heading C2C Novel compounds of Formula I in which R is substituted in the 3- or 4-position of the phenyl group and is hydrogen, C 1-8 alkyl, carbomethoxy, carboxy, carboxamido, dimethylamino, or aminomethyl when substituted in the 4-position or is trifluoromethyl when substituted in the 3-position, and R 1 is phenyl or hydrogen provided that R and R 1 are not simultaneously hydrogen are prepared by hydrogenation of the novel compounds of formula wherein R 2 is R or cyano which are prepared by reacting 2-hydroxypyrimidine with a compound of formula wherein X is halogen. Intermediates are prepared as follows: p-octylbenzyl chloride is obtained by action of thionyl chloride on p-octylbenzyl alcohol prepared by reduction of p-octylbenzoic acid; p-dimethylaminobenzyl chloride hydrochloride is obtained by action of thionyl chloride on the alcohol; and 1 - p - cyanobenzyl) - 2 (1H) - pyrimidone is obtained by reacting α-bromo-p-toluonitrile with 2-hydroxypyrimidine. Pharmaceutical compositions in conventional forms for per oral administration and having anti-convulsant and tranquillizing activity, comprise a novel compound of Formula I above and a carrier therefor. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7244692-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0147894-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6825183-B2 |
| priorityDate | 1971-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.