http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1323775-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J19-00 |
| filingDate | 1970-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1323775-A |
| titleOfInvention | Cardenolide-and bufadienolide-3-2,3-didesoxyglycosides and processes for their preparation |
| abstract | 1323775 Cardial glycosides FARBWERKE HOECHST AG 1 Sept 1970 [29 Aug 1969(2)] 41722/70 Heading C2U The invention comprises compounds of formula where R is a steroid 3-yl radical of the 20(22)- cardenolide or 20,22-bufadienolide series; the two symbols R<SP>1</SP> together represent an epoxy group, or, when R is a cardenolide radical, they each may alternatively represent a hydrogen atom; R<SP>2</SP> is H or an aliphatic, cycloaliphatic, aromatic or araliphatic hydrocarbyl or acyl group; and R<SP>3</SP> is H, Me or CH 2 OR<SP>2</SP>. Preparation of compounds (I) is from compounds of formula by catalytic hydrogenation (for products wherein R<SP>1</SP> = H) or by reaction with an organic peracid (for products wherein R<SP>1</SP>+R<SP>1</SP> = epoxy). Subsequently any 4<SP>1</SP>-acyloxy group may be hydrolysed, or any 4<SP>1</SP>-hydroxy group esterified or etherified. Digitoxigenin 3 - (#<SP>2</SP> - 2,3 - dideoxy - 4 - O- acetyl - D - arabinoside) is prepared by reacting digitoxigenin with di-O-acetyl-D-arabinal. The L-arabinoside isomer is prepared analogously and then hydrolysed to digitoxigenin 3-(#<SP>2</SP>- 2,3-dideoxy-L-arabinoside). Uzarigenin 3 - (#<SP>2</SP> - 2,3 - dideoxy - 4 - O- acetyl-α-L-rhamnoside) is prepared by reacting uzarigenin with di-O-acetyl-L-rhamnal. Other starting materials of Formula II are prepared as described in Specfications 1,268,230, 1,282,019 and 1,323,148. The steroids of Formula (I) are stated to possess cardiotonic, diuretic and antidiarrhoeal activities, and may be made up with carriers into pharmaceutical compositions for oral or parenteral administration. |
| priorityDate | 1969-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.