| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2cfe9476756cbefeb757683dd52adac |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-53 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-36 |
| filingDate |
1969-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23145c29b30d10b9f1f1b0ea3a3d06d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7665c9b7995f37f7a92e7d3db61d94b9 |
| publicationDate |
1973-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-1321424-A |
| titleOfInvention |
N-phenyl-n-disubstituted aminoalkyl-2-amino indanes |
| abstract |
1321424 N-Phenyl-N-disubstituted amino alkyl-2-amino-indanes MANUFACTURE DE PRODUITS PHARMACEUTIQUES A CHRISTIAENS SA 26 Nov 1970 [19 Dec 1969] 62073/69 Heading C2C Novel compounds of formula wherein n is 2 or 3, R 1 and R 2 are C 1 -C 4 alkyl or together with the adjacent nitrogen atom form a heterocyclic ring and R 3 is phenyl optionally substituted by e.g. methyl, methoxy, Cl or CF 3 and acid addition salts thereof, are prepared by reaction of a compound of Formula II with NaNH 2 and Cl(CR 2 ) n N.R 1 .R 2 and optional salt formation. Intermediates of Formula II are prepared by one of the following methods (a) an amine R 3 NH 2 is reacted with a 2-keto-3-cyanoindene and the product reduced by the Bouveault-Blanc method, (b) an amine R 3 NH 2 is reacted with a compound of formula or (c) 2-indanone is reacted with an amine R 3 NH 2 and NaBH 4 is then added to the reaction mixture. Pharmaceutical compositions in conventional forms for topical, parenteral or rectal administration and having local anaesthetic activity or use in treating heart arrhythmia comprise an above novel compound and a suitable carrier or diluent. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1185267-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9044482-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1658847-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6413987-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7592458-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1185267-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2191999-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865741-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1658847-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9375423-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7718674-B2 |
| priorityDate |
1969-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |