http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1321407-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-155 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 |
| filingDate | 1972-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1321407-A |
| titleOfInvention | 1-phenyl-4-amino-cyclohex-2-ene-1-carboxylic acid esters |
| abstract | 1321407 1 - Phenyl - 4 - aminocyclohex - 2- ene-1-carboxylic acid esters WARNER-LAMBERT CO 15 Feb 1972 [18 Feb 1971] 6980/72 Heading C2C Novel compounds of Formula I wherein R 1 and R 2 , which may be the same or different, are hydrogen atoms or alkyl, hydroxyalkyl or alkenyl radicals or aralkyl radicals the alkyl group of which can contain a hydroxy group or wherein R 1 and R 2 together with the nitrogen atom to which they are attached, are either joined directly to form a heterocycle, which is optionally substituted by a hydroxyl group, or joined via an oxygen atom or by a nitrogen atom which carries a hydrogen atom, an alkylradical containing up to 4 carbon atoms, an aryl radical, which may be substituted by chlorine or by methoxy, an acyl radical or an aralkyl radical and R 3 is an alkyl radical containing up to 4 carbon atoms; and the salts and quaternary ammonium compounds thereof are prepared by reaction of a compound of formula R 1 NHR 2 with a compound of Formula II wherein Y is halogen, nitrobenzoyloxy or optionally substituted phenylsulphonyloxy. Intermediates of Formula II above wherein Y is Cl, Br are prepared by reaction of the compound wherein Y is OH with PCl 5 or SOCl 2 , acetyl bromide or methane sulphonic acid chloride respectively or where Y is Cl, by action of HCl on the compound where Y is acetyloxy or where Y is I by action of methyl iodide on the compound where Y is dimethylamino. The compound of Formula II where Y is OH is prepared by saponification of the compound where Y is acetyloxy itself obtained by reaction of crotonaldehyde, acetic anhydride and ethyl atropate with sodium acetate. Pharmaceutical compositions in conventional forms for oral or parenteral administration having analgesic and neuroleptic properties and spasmolytic activity comprise an above novel compound and a pharmaceutical diluent or carrier. |
| priorityDate | 1971-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.