http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1312133-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61C19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G03B17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G03B17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61C19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 |
| filingDate | 1970-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1312133-A |
| titleOfInvention | 2-thienyl-3-amino-1,3-diazacycloalkenes and process for preparing them |
| abstract | 1312133 Thienylamino - 1,3 - diazacycloalkenes FARBWERKE HOECHST AG 14 Aug 1970 [16 Aug 1969] 39303/70 Heading C2C Novel compounds of Formula I (in which each of R 1 , R 2 and R 3 is H, C 1-5 alkyl, halogen, CN or phenyl, or R 2 and R 3 together form a trimethylene or tetramethylene chain, and Z is C 2-4 alkylene in which 2 or 3 carbon atoms are members of the diazacycloalkene ring) and their acid addition salts, are prepared by (a) reacting a compound of Formula II (in which R is -C(=NH)SR 5 .HX, -CSNH 2 , -C(=NH)NH 2 , -C(=NH)NH 2 .HX, -C(=NH)NHNO 2 or -CN, where R 5 is C 1-5 alkyl and X is an acid anion) with a diamine of formula H 2 N-Z-NH 2 , or a mono acid addition salt thereof, or (b) cyclizing a compound of Formula III e.g. by heating to 150 to 200 C., or (c) reacting a compound of Formula IV with a compound of V or an acid addition salt thereof, or (d) reacting a compound of Formula IV with a compound of Formula VI or (e) reacting a compound of Formula VII in which each Hal is Cl or Br, with a diamine of formula H 2 N-Z-NH 2 or a mono acid addition salt thereof. Resulting compounds I may be converted into acid addition salts or, when at least one of R 1 , R 2 and R 3 is H, may be halogenated to replace the H atom(s) by halogen atom(s). Starting materials.-The following compounds are characterized in the examples: 3<SP>1</SP>-thienyl- S - methyl - isothiouronium hydroiodide, 4<SP>1</SP>- methylthienyl - 3<SP>1</SP> - S - methyl - isothiouronium hydroiodide, N - 3 - thienyl - thiourea, 4 - methylthienyl - 3 - thiourea, 4 - methylthienyl - 3- guanidine hydrochloride, N - (4 - methylthienyl- 3) - N<SP>1</SP> - (2 - amino - ethyl) - thiourea, 4 - methylthienyl - 3 - nitroguanidine and 4 - methylthienyl- 3-cyanamide. Pharmaceutical compositions having blood pressure lowering properties comprise a compound of Formula I, or a physiologically tolerable acid addition salt thereof, together with a pharmaceutical carrier. |
| priorityDate | 1969-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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