| abstract |
1301820 Preparation of methoxynaphthylpropionic acid and intermediates therefor SYNTEX CORP 20 Jan 1970 [30 Sept 1969] 31639/72 Divided out of 1300591 Heading C2C 2 - (6-Methoxy- 2-naphthyl)propionic acid is prepared by reacting a compound I wherein M is MgCl, MgBr, MgI, Li, Na, K, Zn/2 or Cd/2, with CO 2 ethyl orthocarbonate or ethyl chloroformate, and treating the mixture with acid and optionally resolving a dl-mixture thus formed. Compounds I are claimed per se and are prepared (a) by reacting 1-bromo-1-(6-methoxy-2- naphthyl)-ethane with Mg, Li or Zn to give I where M is MgBr, Li or Zn/2, or (b) reacting the product of (a) with CdCl 2 ,Na or K to give I where M is Cd/2, Na or K. Pharmaceutical compositions comprising 2- (6 methoxy- 2-napthyl)propionic acid when prepared as above, together with a suitable excipient are used in treating inflammation, pain and pyrexia. |