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filingDate 1970-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_698827d68842f416f30b78fd57413e35
publicationDate 1972-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1298494-A
titleOfInvention Phenylethanolamine derivatives
abstract 1298494 Phenylethanolamine derivatives ALLEN & HANBUKYS Ltd 18 May 1971 [17 June 1970] 29367/70 Heading C2C R- and S - α<SP>1</SP> - tert. - butylaminomethyl - 4- hydroxy - m - xylene - α<SP>1</SP>,α<SP>3</SP> - diol and their acid addition salts are prepared by resolving a C 1-6 alkyl 5 - (2 - benzyl - tert. - butylamino - 1- hydroxyethyl) - 2 - benzyloxybenzoate with (- ) or ( + ) di-p-toluoyltartaric acid followed by reduction of the alkoxycarbonyl group to hy. droxymethyl and removal of the benzyl groups, the product being isolated as the free base or a salt. The preparation of the methyl ester starting material is described. The above compounds are bronchodilators and may be administered in the form of pharmaceutical preparations containing them, with or without other active ingredients, in association with a carrier.
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