http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1298157-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2e3d9792e0546ce6a766cc0e439b28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-68 |
| filingDate | 1970-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1298157-A |
| titleOfInvention | BENZO-(b)-THIOPHENE DERIVATIVES AND COMPOSITIONS CONTAINING THE SAME |
| abstract | 1298157 Benzo(b)thiophene derivatives CENTRE D'ETUDES POUR L'INDUSTRIE PHARMACEUTIQUE 6 March 1970 [7 March 1969] 10973/70 Heading C2C Novel benzo(b)thiophene derivatives of the formula wherein A is C 1-6 alkylene; and R and R<SP>1</SP>, which may be the same or different, each are H, or optionally substituted alkyl, cycloalkyl or aralkyl, or R and R<SP>1</SP> together with the nitrogen atom to which they are attached form a 5-7. membered saturated heterocyclic ring, optionally containing further hetero atoms, and/or opt - ionally substituted by one or more C 1-4 alkyl or C 1-4 hydroxyalkyl groups; and acid addition and quaternary ammonium salts thereof, are prepared by reacting the appropriate 3-carbamoyl - 2 - haloacylamino - 4,5,6,7 - tetrahydrobenzo(b)thiophenes with compounds of the formula 2 - (Chloroacetylamino)- 3 - carbamoyl - 4,5,6, 7 - tetrahydrobenzo(b)thiophene and 2 - (3- bromopropionylamino)- 3 - carbamoyl - 4,5,6,7- tetrahydrobenzo(b)thiophene are obtained by reacting 2 - amino - 3 - carbamoyl - 4,5,6,7 - tetrahydrobenzo(b)thiophene with chloroacetyl chloride and 3-bromopropionyl bromide respectively. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above novel compounds or physiologically acceptable acid addition or quaternary ammonium salts thereof, in association with pharmaceutical carriers and/or excipients. The compositions have anti-arrhythmic, anti-histaminic, anti-tussive and anti-inflammatory activities and may also be used as local anaesthetics. |
| priorityDate | 1969-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.