http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1297386-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01B3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01B3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-14 |
| filingDate | 1969-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5024aca53afc80bea93b5dbcfa55a2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ec392bea0d808886c9702febaa2c2b5 |
| publicationDate | 1972-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1297386-A |
| abstract | 1297386 Dibenzothiepin and dibenzoxepin derivatives CIBA GEIGY AG 26 Nov 1969 [27 Nov 1968] 57849/69 Heading C2C Novel compounds of Formula I: (in which X is O or S, Y is H, Cl, CH 3 , CH 3 O or CH 3 S and R is H, straight chain C 1-6 alkyl, isopropyl or allyl) and their pharmaceutically acceptable acid addition salts, are prepared (i) when R is not H, by reacting a compound of the Formula II: with an amine of formula RNH 2 (in which R is as defined above except for H), or (ii) when R is H, by hydrolysing a compound of Formula III: (in which R is CN or the acyl radical of an organic acid), and, if desired, converting a compound I thus obtained into a pharmaceutically acceptable acid addition salt. Starting materials of Formula III in which Y is ethoxycarbonyl, are prepared by reacting a compound of Formula IV; (in which R 2 is C 1-6 alkyl, allyl or benzyl) with ethyl chloroformate. Pharmaceutical compositions having central depressant and antihistaminic activity, for oral, rectal or parenteral administration, comprise a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutically acceptable diluent or carrier. |
| priorityDate | 1968-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.