http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1296159-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1970-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1296159-A |
| abstract | 1296159 6α - Methyl - 17α - hexanoyloxy - 19 - nor - progesterone CIBA-GEIGY AG 9 Oct 1970 [10 Oct 1969] 48139/70 Heading C2U The novel title compound is prepared (1) by reduction of compounds of the formula (wherein R 1 is a free or ketalized oxo group, R 2 is a free or esterified OH group and R 3 is a hydrocarbon or acyl radical), or (2) by selective reduction of compounds of the formula where X is one of the structures or (3) by elimination of water from compounds of the formula with subsequent hydrolysis when required of any enol ether or ketal group and/or caproylation of a free 17α-OH group, with isolation of the 6α-methyl compound from the resulting epimer mixture at any stage, possibly after enrichment in the required epimer. 3 - Methoxy 6 - formyl - 17α - caproyloxy - 20 - oxo - A<SP>3</SP>'<SP>5</SP> - 19 - nor - pregnadiene is prepared by Vilsmeier formylation of 3 - methoxy - 17α - caproyloxy - 20 - oxo - A<SP>3</SP>'<SP>5</SP> - 19 - nor - pregnadiene (prepared in turn from 17α-caproyloxy-19-norprogesterone) and is converted into 3,20-dioxo-6- methylene - 17α - caproyloxy - #<SP>4</SP> - 19 - nor - pregnene by NaBH 4 reduction and treatment of the product with acetic acid. 3,20 - Dioxo - 6α - methyl - 17α - hydroxy - #<SP>4</SP> - 19 - nor - pregnens is prepared by converting 17α - acetoxy - 19 - nor - progesterone to 3 - oxo - 5α,17α - dihydroxy - 6# - methyl - 20,20 - ethylenedioxy - 19 - nor - pregnene by a series of reactions and then dehydrating and hydrolysing this with epimerization of the 6#- methyl product produced. The novel steroid is stated to have a high progestative and ovulation-inhibiting activity and to be of use as a gestagen and for fertility control. It can be made up into pharmaceutical compositions with suitable carriers. |
| priorityDate | 1969-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.