http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1294541-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 |
| filingDate | 1970-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1294541-A |
| titleOfInvention | Cephalosporanic acid derivatives |
| abstract | 1294541 Cephalosporanic acids BRISTOLMYERS CO 21 Jan 1970 [21 Jan 1969] 3011/70 Heading C2A Novel α-acylureidocephalosporin derivatives of Formula (I) wherein Ar is 2-thienyl, 3-thienyl or in which each of R<SP>1</SP> and R<SP>2</SP> is -H, -NO 2 , -NH 2 , -OH, -Cl, -Br, -I, -F, -CF 3 , C 1 to C 6 alkyl, C 1 to C 6 alkoxy, di-(C 1 to C 6 )-alkylamino, C 1 to C 6 alkanoylamino, C 1 to C 6 alkanoyloxy, or sulphamyl; A is hydrogen, acetoxy, pyridinium, picolinium or lutidinium; M is hydrogen, a non-toxic cation or when A is one of the said quaternary ammonium radicals, an anionic charge, and Z is C 1 to C 6 alkyl, C 4 to C 7 cycloalkyl, monohalo-(C 1 to C 6 )-alkyl, di- or tri-chloromethyl, C 2 to C 6 alkenyl, or a group of formula in which n is 0 to 3 and each of R<SP>3</SP> and R<SP>4</SP> is -H, -NO 2 , -Cl, -I, -Br, -F, -CF 3 , C 1 to C 6 alkyl, C 1 to C 6 alkoxy, C 1 to C 6 alkanoyloxy, C 1 to C 6 alkanoylamino, di-(C 1 to C 6 )-alkylamino or sulphamyl, are prepared by (a) reacting an α-aminoarylacetamidocephalosporanic acid (aryl includes 2- or 3-thienyl) or corresponding desacetoxycephalosporanic acid with an acyl isocyanate of formula Z-CO-NCO where Z is as above, in the presence of a base in an anhydrous inert solvent at - 20‹ to 50‹ C. for at least 30 minutes, and if required, when A is acetoxy, converting it to pyridinium, picolinium or lutidinium; or (b) reacting 7-aminocephalosporanic acid or 7-aminodesacetoxycephalosporanic acid with an acid of formula wherein Ar and Z are as above, or with its N- caylating functional equivalent. Pharmaceutical compositions having antibiotic activity against gram-positive and gramnegative bacteria comprise a cephalosporin of Formula (I) as defined above together with a pharmaceutically acceptable carrier. |
| priorityDate | 1969-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.