http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1293626-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-2055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-673 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-05 |
| filingDate | 1970-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6dc42a10efd81a6175576c4d1b450fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df8fb6bda7277ae5a2e8cc551fdcd3c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3349e93cb8c5f9a494c6f6d897250d59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7d0af82f04b6db196cb04b9183ebc15 |
| publicationDate | 1972-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1293626-A |
| titleOfInvention | Substituted salicylic acid compounds |
| abstract | 1293626 Substituted salicylic acids MERCK & CO Inc 18 June 1970 [25 June 1969 20 April 1970] 29543/70 Heading C2C Novel compounds of formula wherein R is hydroxy, amino, alkoxy, alkylamino, dialkylamino, dialkylaminoalkylamino, dialkylaminoalkoxy, hydroxyalkoxy, polyhydroxyalkoxy, alkoxyalkoxy, phenylalkoxy, phenoxy, alkoxyphenoxy, halophenoxy, dialkylaminophenoxy, alkanoylaminophenoxy, carboxyphenoxy, alkoxycarbonylphenoxy, alkanoylaminoalkoxy, anilino, hydrazino, morpholino,N-piperidino, pyrrolidino or hydroxyalkylamino ; R 2 is hydrogen, acyl, alkyl or alkoxycarbonyl ; R 3 is hydrogen, halogen, haloalkyl, alkyl, cycloalkyl or alkoxy; and each X is hydrogen, alkyl, hydroxy, alkoxy, acyloxy, halogen, haloalkyl, nitro, amino, alkylamino, dialkylamino, acylamino, mercapto, alkylthio, alkylsulphinyl, alkylsulphonyl, sulphamoyl, sulphinylamido, aminoalkyl, alkylaminoalkyl, hydroxyalkyl, alkoxyalkyl, mercaptoalkyl, alkylthioalkyl, cyano, carboxy, alkoxycarbonyl, carbamoyl, aryl, aralkyl, salicyl, aryloxy or aralkoxy; and Y is methylene, carbonyl, methylenecarbonyl, cyclopropylene, cyclopropylidene or iminocarbonyl; provided that the OR 2 group is always ortho to the group, that when Y is carbonyl, X may not be a halogen other than fluorine, that when Y is methylene, at least one X is other than hydrogen, halogen or amino, and the Xs are such that the compound is not a symmetrical or symmetrically substituted bis-(hydroxycarboxyphenyl)-methane, and that none of the alkyl and alkoxy radicals contain more than 5 carbon atoms and alkanoyl residues contain less than 6 carbon atoms and salts and anhydrides thereof are prepared (a) by carbonation of a compound of Formula II: optionally followed by conversion of the X, hydroxy and/or carboxylic groups into other values given above by standard methods, or (b) by reaction of the appropriate acid chloride with salicylic acid or a derivative thereof in the presence of a Friedel-Crafts catalyst. p-(4-Fluorobenzoyl)-phenol is prepared by demethylation of p-(4-fluorobenzoyl)-anisole obtained by reaction of anisole with p-fluorobenzoic acid and polyphosphoric acid or directly by using phenol for anisole in the last reaction. 4-(p-Fluorobenzoyl)-m-cresol is prepared by reaction of m-cresol and p-fluorobenzoyl chloride in presence of AlCl 3 . ( p-Methoxyphenyl ) - (p-methylphenyl) -methane is prepared by reduction of 4-methoxy-4<SP>1</SP>-methylbenzophenone. Pharmaceutical compositions in conventional forms for oral, rectal, topical or parenteral administration and having anti-inflammatory activity comprise an above novel compound and a carrier or diluent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4996230-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5683682-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-601541-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5171882-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4992576-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5235064-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0276064-A1 |
| priorityDate | 1969-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.