http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1283451-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d269c8e41f178194d858c230c9f85e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 |
| filingDate | 1970-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d497c6c8eb6fae858b8af2a2dd0e106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bed404dde9a3ccbc6fc5de488a934e2b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13c199fcdb0843b2735583efd7dd7e5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51e6a0fbc70c05ca6c55c6f77be51161 |
| publicationDate | 1972-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1283451-A |
| titleOfInvention | Ortho-substituted phenol ethers, their preparation and compositions containing them |
| abstract | 1283451 o-Vinylphenol ethers PFIZER Ltd 19 April 1971 [13 March 1970] 12111/70 Heading C2C Novel o-vinylphenol ethers of the general formula wherein R<SP>1</SP> is a saturated aliphatic or alicyclic hydrocarbon radical containing at least 5 carbon atoms, Y is either (A) a -Alk-NR<SP>2</SP>R<SP>3</SP> group, in which R<SP>2</SP> and R<SP>3</SP> are each a C 1-4 alkyl group or NR<SP>2</SP>R<SP>3</SP> is a saturated heterocyclic group and Alk is a divalent saturated aliphatic hydrocarbon group containing 2-4 carbon atoms, the free valencies being located on different carbon atoms, or (B) a group of the formula in which n is 0-3 and Z is a divalent group which completes a saturated heterocyclic ring containing at least one nitrogen atom and at least 4 carbon atoms, any such nitrogen atom being separated from the oxygen atom to which Y is attached by a chain of 2-4 carbon atoms, and R<SP>4</SP> is a hydrogen or halogen atom or a C 1-4 alkyl or alkoxy group, and their pharmaceutically-acceptable acid addition salts are prepared (a) by reaction of an alkali metal salt of an o-vinylphenol of the general formula with a halide of the general formula wherein hal is a halogen atom; (b) when Y is a -Alk-NR<SP>2</SP>R<SP>3</SP> group, by reaction of an o-vinylphenol haloalkyl ether of the general formula with an amine of the general formula HNR<SP>2</SP>R<SP>3</SP>; (c) by dehydration of an o-(1-hydroxy-ethyl)- phenol ether of the general formula or dehydrohalogenation of the corresponding o-(1-haloethyl)-phenol ether; and (d) when R<SP>4</SP> is a hydrogen atom or an alkyl or alkoxy group, by dehydration of an o-(2-hydroxyethyl)-phenol ether of the general formula or dehydrohalogenation of the corresponding o-(2-haloethyl)-phenol ether; followed optionally by salification of the product. o-(1-Hydroxyethyl)-phenol ethers of the seventh general formula above are prepared (a) by reaction of a salicylaldehyde of the general formula with magnesium or lithium and a halide of the general formula hal-CH 2 -R<SP>1</SP> or (b) by reduction of an o-acylphenol ether of the general formula (which is prepared, when Y is (A), by reaction of a 4-R<SP>4</SP>-phenol and a carboxylic acid of the general formula R<SP>1</SP>CH 2 COOH in the presence of a Lewis acid and (i) reaction of the resulting o-acylphenol of the general formula with a halide of the general formula hal-Alk-Q, wherein Q is an arylsulphonyloxy group, and reaction of the resulting o-acylphenol hal-Alk ether with an amine of the fifth general formula above or (ii) reaction of said o-acylphenol with an alkali metal compound and a halide of the third general formula above). Pharmaceutical compositions having antihistamine activity comprise, as active ingredient, an o-vinyl-phenol ether of the first general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutical carrier or diluent, and may be administered orally or parenterally. |
| priorityDate | 1970-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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