http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1279843-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c4cb9b5558ad97d3acc0db1113f7727 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-13 |
| filingDate | 1969-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96228c1cdec2d037c6753fe98dad9934 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a33403de2826f0332961c92539fc5847 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_025355016ad9432d561367b6b8f3acb8 |
| publicationDate | 1972-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1279843-A |
| titleOfInvention | Benzamidoethyl-piperazines and process for their preparation |
| abstract | 1279843 Piperazine derivatives SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 26 May 1970 [23 May 1969] 26437/69 Heading C2C The invention comprises novel piperazine derivatives of the Formula I: wherein R 1 is H, C 1-4 alkoxy, NH 2 or C 1-4 acylamino ; R 2 is H, halogen, C 1-4 alkyl or NH 2 ; or R 1 and R 2 together are methylenedioxy; R 3 is H, halogen, C 1-4 alkoxy, OH or NH 2 ; R 4 is H, C 1-4 alkyl or C 2-4 alkenyl; and R 5 is (a) a radical of the formula in which n is 0 to 3; R is H, phenyl or halophenyl, and Y is H, halogen, C 1-4 alkoxy or methylenedioxy, (b) pyrimidyl or pyrazinyl; (c) 2- or 4-pyridyl of the formula or the corresponding N-oxides, in which R<SP>1</SP> is H, C 1-4 alkyl or C 1-4 alkoxy, and acid addition salts thereof. The above novel compounds are prepared by reacting benzoic acid derivatives of the formula wherein Z is C1 or OCOCH 2 CH 3 , R<SP>1</SP>1 is H, C 1-4 alkoxy, NO 2 , or C 1-4 acylamino, R<SP>1</SP> 2 is H, halogen, C 1-4 alkyl or NO 2 , or R<SP>1</SP> 1 and R<SP>1</SP> 2 together are methylenedioxy, R<SP>1</SP> 3 is H, halogen, C 1-4 alkoxy or NO 2 , with the appropriate piperazine derivatives and where R<SP>1</SP> 1 and/or R<SP>1</SP> 2 and/or R<SP>1</SP> 3 are NO 2 , reducing the thus obtained nitro compounds with hydrogen in the presence of a catalyst. Alternatively compounds of the above Formula I in which R 1 is acylamino may be obtained by the acylation of the corresponding compounds in which R 1 is NH 2 , and compounds in which R 1 is NH 2 by the hydrolysis of the corresponding compounds of Formula I in which R 1 is CH 3 CONH. 1 - Aminoethyl - 4 - (2 - pyridyl) - piperazine, 1 - aminoethyl - 4 - piperonyl - piperazine, and 1 - aminoethyl - 4 - (bis - p - fluorobemhydryl)- piperazine are prepared by reacting ethyleneimine with 1 - (2 - pyridyl) - piperazine hydrochloride 1 - piperonylpiperazine and 1- (bis - p - fluorobenzhydryl) - piperazine respectively. Pharmaceutical compositions, having broncholytic, anti-anaphylactic and gastric anti-secretory properties, contain the above novel compounds or acid addition salts thereof, in admixture or conjunction with pharmaceutically suitable carriers. The compositions are in forms suitable for oral, parenteral or rectal administration. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-577802-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6127357-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0318933-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009504705-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0138280-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4778796-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0318933-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4510140-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-018046-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2007310588-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4591590-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8481527-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0138280-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008050168-A1 |
| priorityDate | 1969-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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