http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1274152-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-17 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-40 |
| filingDate | 1970-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6dc42a10efd81a6175576c4d1b450fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8e7feba6871b5f812f162dc7ff5a6d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df8fb6bda7277ae5a2e8cc551fdcd3c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3349e93cb8c5f9a494c6f6d897250d59 |
| publicationDate | 1972-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1274152-A |
| titleOfInvention | Anti-inflammatory compositions and their use |
| abstract | 1,274,152. Pharmaceutical compositions. MERCK & CO. Inc. 18 June, 1970 [25 June, 1969; 20 April, 1970], No. 29666/70. Heading A5B. [Also in Division C2] A pharmaceutical composition comprises (a) a compound of formula wherein Y is CH 2 or CO, R is OH, NH 2 , C 1-5 alkoxy, C 1-5 alkylamino, di (C 1-5 alkyl) amino, di (C 1-5 alkyl) amino (C 1-5 alkyl) amino, di (C 1-5 alkyl) amino (C 1-5 alkoxy), hydroxy (C 1-5 alkoxy), polyhydroxy (C 1-5 alkoxy), (C 1-5 alkoxy) (C 1-5 alkoxy), aryl (C 1-5 alkoxy), phenoxy, (C 1-5 alkoxy) phenoxy, (C 1-6 alkanoyl) amino-phenoxy, di (C 1-5 alkyl) aminophenoxy, (C 1-6 alkanoxyl) amino (C 1-5 alkoxy), hydrazino, hydroxy (C 1-5 alkyl) amino, hydroxylamino, morpholino, N - pyrrolidinyl, piperidino, N - [4 - (C 1-5 alkyl)], piperidino, N - [4 - hydroxy (C 1-5 alkyl] piperidino or a naturally occurring amino-acid radical attached at the nitrogen atom, R 2 is H, C 1-6 acyl, C 1-5 alkyl or C 2-6 alkoxy - carbonyl and X is H, alkyl, OH, alkoxy, acyloxy, halogen, haloalkyl, nitro, amino, alkylamino, di (C 1-5 alkyl) amino, acylamino, mercapto, alkylthio, alkylsulphinyl, alkylsulphonyl, arylsulphonyl, sulphamoyl, aminosulphinyl, aminoalkyl, alkyllaminoalkyl, hydroxyalkyl, alkoxy alkyl, mercaptoalkyl, alkylthioalkyl, cyano, carboxy, alkoxycarbonyl, carbamyl, aryl, aralkyl, aryloxy, aralkoxy, or acyl and the RCO group is ortho to the R 2 O group, or a non-toxic salt or anhydride of such compound in which R is OH and (b) an oily liquid or solid carrier. Particular active ingredients specified are 7 - fluoro - 2 - hydroxyfluorene - 1 - carboxylic acid, 7 - fluoro - 2 - hydroxy -fluorene - 3 - carboxylic acid, 7 - chloro - 2 - hydroxyfluorene - 1 - carboxylic acid, 7 - chloro - 2 - hydroxyfluorene - 3 - carboxylic acid, 7 - acid, 6 - fluoro - 2 - hydroxyfluorene - 1 - methoxy - 2 - hydroxyfluorene - 1 - carboxylic carboxylic acid, 6 - fluoro - 2 - hydroxyfluorene - 3 - carboxylic acid, 7 - dimethylamino 2 - hydroxyfluorene - 3 - carboxylic acid, 7 - trifluoromethyl - 2 - hydroxyfluorene - 1 - carboxylic acid, 7 - trifluoromethyl - 2 - hydroxyfluorene - 3 - carboxylic acid, 7 - fluoro - 2 - hydroxyfluorenone - 1 - carboxylic acid, 7 - fluoro - 2 - hydroxyfluorenone - 3 - carboxylic acid, methyl 7 - fluoro - 2 - hydroxyfluorene - 3 - carboxylate, 7 - fluoro - 2 - hydroxyfluorene - 3 - carboxyamide, 7 - fluoro - 2 - methoxyfluorene - 3 - carboxylic acid, and 7 - fluoro - 2 - acetoxy fluorene - 3 - carboxylic acid. Carriers specified include lactose, corn starch, magnesium stearate, sucrose, poly (ethylene glycol) mono cetyl ether, polyvinyl pyrrolidone, methyl p - hydroxybenzoate, gum acacia, tragacanth and elixir of saccharin. The composition may also include colouring and flavouring matter. Water may be present together with another carrier. The compositions may be used in the form of a tablet, capsule, troche, lozenge, powder, suppository, syrup, liquid suspension, pill, cream, gel, ointment, lotion, elixir or buffered sterile injectable medium. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1223209-A1 |
| priorityDate | 1969-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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