http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1257266-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-147 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 |
| filingDate | 1969-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1257266-A |
| abstract | 1,257,266. Alkenoic acids. BEECHAM GROUP Ltd. 30 July, 1970 [5 Aug., 1969], No. 39123/69. Heading C2C. Novel alkenoic acids of the Formula I wherein R is C 1-6 alkyl, H or halogen; X is -CH 2 - or -CH 2 .CH(CH 3 )-; R 1 is H, C 1-6 alkyl or C 6-10 aryl ; R 2 is H or COOH ; and each of R 3 and R 4 is H or C 1-6 alkoxy; except that when R 1 to R 4 are all hydrogen atoms, R is not a hydrogen atom, and non-toxic salts, esters and amides thereof are prepared by reacting compounds of the Formula II wherein Z is halogen or a reactive sulphonic acid ester group with malonic acid derivatives of the Formula III wherein M is an alkali metal and R 5 is C 1-6 alkyl and, if desired, hydrolysing the resulting esters to give compounds of Formula I above in which R 2 is COOH and optionally decarboxylating these to give compounds of Formula I in which R 2 is H, and optionally forming salts, esterifying or forming amides. Compounds of the Formula I in which X is -CH 2 CH(CH 3 )- and R 1 and R 2 are H may also be obtained from the corresponding acid chlorides of the acids of Formula I in which X is CH 2 , R 1 is CH 3 and R 2 is H by the Arndt-Cistert reaction. 1 - Diazo - 3,5 - dimethyl - 6,6 - diphenylhex-5- en-2-one is obtained by reacting diazomethane with 2,4 - dimethyl - 5,5 - diphenylpent - 4 - enoic acid chloride, resulting from the treatment of the acid with thionyl chloride. 4,5 - Dibromo - 5,5 - diphenyl - 2 - methyl valeric acid is obtained by brominating 2-methyl- 5,5 - diphenylpent - 4 - enoic acid. 1 - Bromo - 3,3 - diphenylprop - 2 - ene is made by reacting HBr with 3,3-diphenylprop-2-en-1-ol resulting from the reaction of vinyl magnesium bromide on benzophenone. 1 - Bromo - 3,3 - diphenyl - 2 - methylprop - 2- ene and 1 - bromo - 3,3 - diphenyl - 2 - ethylprop- 2-ene are obtained by reacting the corresponding alcohols with hydrobromic acid. 3,3 - Diphenyl - 2 - methyl - 2 - en - 1 - ol, 1,1- diphenyl - 2 - hydroxymethylbut-1-ene, and 1,1- diphenyl - 2 - hydroxymethylpent - 2 - ene are made by reducing the ethyl esters of the appropriate acids. 2 - Methyl - 3 - phenyl - 3 - (4 - methyoxphenyl)- prop-2-enoic acid is obtained by hydrolysing the ethyl ester resulting from the condensation of 4-methoxy-benzophenone and ethyl α-bromopropionate. 2 - Methyl - 3,3 - di - (4 - methoxyphenyl) -prop- 2-enoic acid is prepared from 4,4-dimethoxybenzophenone and ethyl α-bromopropionate. Pharmaceutical compositions, having estrogenic properties and suitable for oral or parenteral administration contain the above novel compounds and pharmaceutically acceptable carriers. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4904661-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5021414-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5182301-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5206403-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0238973-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0238973-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0479332-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4732912-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0479332-A3 |
| priorityDate | 1969-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.