| abstract |
1,247,384. Propanolamine derivatives. MAY & BAKER Ltd. 20 Dec., 1968 [2 Aug., 1968; 22 Dec., 1967; 14 May, 1968], Nos. 37103/68. 56512/68 and 56513/68. Divided out of 1,231,783. Heading C2C. Compounds of the general formula (R<SP>1</SP> = alkanoylamino containing not more than ten carbon atoms, R<SP>2</SP> = alkyl, R<SP>3</SP> = alkyl, cycloalkyl, aralkyl) and their salts are prepared by reacting a compound of the formula with R<SP>3</SP>NH 2 , optionally followed by salt formation. The starting materials are prepared by reacting a compound of the formula (M = H or alkali metal) with epichlorohydrin. The phenols and their metal derivatives are prepared by standard methods. The compounds of the invention are selective #-adrenergic blocking agents, and may be administered in the form of pharmaceutical preparations containing them in association with a. carrier. |