http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1240224-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 |
| filingDate | 1969-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d22968f8bcf3ac20d9e62297205b4231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c02a168a2d69af849b94af3bed42c443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66b4f2339c1017d11d30f7f42e1ec14c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2615ca562a3d34eefc235c2fb8d25f33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99aa80d6685e50c6bca3bcde46497004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ba338fb0bf191bb82b01c2cfb199b1d |
| publicationDate | 1971-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1240224-A |
| titleOfInvention | Improvements in or relating to hydroxylamine derivatives |
| abstract | 1,240,224. Hydroxamic acid derivatives. RICHTER GEDEON VEGYESZETI GYAR RT. 25 March, 1969 [30 March, 1968], No. 15666/69. Heading C2C. Novel hydroxamic -acid derivatives of the formula wherein Ac is an acyl radical of a carboxylic acid containing one or more basic nitrogen atoms, with the exception of the amino acids leucine, valine and alanine, and of 4 - phenyl - 1,2,5,6 - tetrahydropyridinoalkanoic acids, and X is an unsubstituted or substituted aralkyl radical and the pharmaceutically acceptable acid addition salts thereof -are prepared either by reacting an O - substituted hydroxylamine of the formula H 2 N-O-X with an acid of the formula AcOH or reactive derivative thereof or by reacting an N-acylated (hydroxylamine of the formula AcNHOH with an aralkyl halide of the formula X-Hal. If desired the basic nitrogen atom in the above starting materials may be protected and the protective groups removed at the end of the above processes to give the desired products. N - (tert. - Butyloxycarbonyl) - L - prolyl- O - benzyl - hydroxylamine is obtained either by reacting O - benzyl - hydroxylamine with N- (tert. - butyloxycarbonyl) - L - proline pentachlorophenyl ester or by reacting benzyl chloride with N - tert. - butyloxycarbonyl - L - proline hydroxamic acid. N - (tert. - Butyloxycarbonyl) - L - prolyl - 0- p - nitro - benzyl - hydroxylamine, N - (tert. - butyloxycarbonyl) - L - seryl - 0 - p - chlorobenzyl - hydroxylamine, N - (tert. - butyloxycarbonyl) - L - seryl - O - benzyl - hydroxylamine, N - carbobenzoxy - L - phenylalanyl - O - benzylhydroxylamine, N - carbobenzoxy - glycylglycyl- O - benzyl - hydroxylamine, and N - carbobenzoxy- L - seryl - O - benzyl - hydroxylamine are prepared by reacting the appropriate o-substituted hydroxylamine with the corresponding amino acid or amino acid ester. Pharmaceutical compositions, suitable for oral, parenteral or rectal administration, contain the above-novel compounds or pharmaceutically acceptable acid addition salts thereof and suitable carriers or diluents. The compounds possess hypotensive activity and some of them also show sedative or hypnotic effects. |
| priorityDate | 1968-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.