http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1240013-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 |
| filingDate | 1968-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1240013-A |
| titleOfInvention | Preparation of oxygen containing indole derivatives |
| abstract | 1,240,013. Indole derivatives. INSTITUT PASTEUR. 2 Aug., 1968 [17 Aug., 1967], No. 37014/68. Heading C2C. A method of preparing 4,5,6,7 - tetrahydro indolone derivatives bearing an oxo group at positions 4 or 7, comprises cyclizing in an acid medium a 4 - (2 - pyrrolyl) - butyric acid or a nitrile or alkoxycarbonic anhydride thereof, optionally having substituents in its aliphatic chain and/or in its pyrrolic nucleus. Polyphosphoric acid, or an acidic metal halide may be used to provide the acid medium for the cyclization reaction, which is preferably carried out in the cold. Separation of an isomeric mixture of products may be effected chromatographically. The 4,5,6,7 - tetrahydro - indolone formed may be dehydrogenated and its keto group reduced to give either 4- or 7-hydroxyindole, for example by catalytic dehydrogenation on a palladium catalyst. Alkoxy-indoles may be produced by alkylation of the hydroxy group with an alkali metal hydride and alkyl halide. |
| priorityDate | 1967-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.