http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1237062-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f88f84fc279fe5d0b9b5ec3c88c2e2b2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 |
| filingDate | 1969-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1237062-A |
| titleOfInvention | ESTERS OF alpha-(1-SUBSTITUTED-3-PYRROLIDINYL)-alpha-PHENYL-ACETIC ACID |
| abstract | 1,237,062. α - (1 - Substituted - 3 - pyrrolidinyl)-α-phenylacetic acid esters. A. H. ROBINS CO. Inc. 6 Jan., 1969 [26 Feb., 1968], No. 732/69. Heading C2C. Novel α - (1 - substituted - 3 - pyrrolidinyl)- α-phenylacetic acid esters of the general formula wherein R is a C 1-8 alkyl or C 3-9 cycloalkyl group, R<SP>1</SP> is a hydrogen atom or a C 1-8 alkyl or phenyl group and R<SP>2</SP> is a C 1-8 alkyl group, and acid addition salts thereof are prepared by hydrolysis of an α-(1-substituted-3-pyrrolidinyl)- a-phenylacetonitrile of the general formula wherein Z is a 1-R-3-pyrrolidinyl group, and treatment of the resulting α-(1-substituted-3- pyrrolidinyl)-α-phenyl-acetic acid of the general formula either with a thionyl halide, followed by an appropriate alkoxide or with a C 1-8 alkanol followed optionally by salification. 4-(#-Chloroethyl) - 3,3 - diphenyl - 1 - R - 2 - pyrrolidinones are obtained as by-products when thionyl chloride is used. Pharmaceutical compositions having analgesic activity comprise, as active ingredient, an α-(1- substituted - 3 - pyrrolidinyl) - α - phenylacetic acid ester of the first general formula above or an acid addition salt, together with a pharmaceutical carrier and may be administered orally or parenterally. |
| priorityDate | 1968-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 16.