http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1234508-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-28 |
| filingDate | 1969-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1234508-A |
| abstract | 1,234,508. L - 3 - Hydroxy - 6 - oxomorphinan compounds. SHIONOGI & CO. Ltd. 21 March, 1969 [21 March, 1968], No. 14999/69. Heading C2C. Novel L 3 - hydroxy - 6 - oxomorphinan compounds of the formula wherein L signifies a morphinan conformation similar to those derived from thebaine, R represents H or OH, R 1 represents allyl, γ,γ - dimethylallyl or cyclopropylmethyl, and F represents the presence or absence of a double bond, and physiologically acceptable acid addition salts thereof, are obtained by reacting a morphinan compound of the formula with a halogen compound R 1 -X, where X is a halogen atom, in an inert solvent medium. The morphinans of Formula II can be obtained by reacting a corresponding N-methylmorphinan with cyanogen bromide in chloroform to form an N-cyanomorphinan and heating the latter with hydrochloric acid. Pharmaceutical compositions having action as narcotic antagonists and also useful as non- narcotic analgesic, sedative and antitussive agents, comprise compounds of Formula (I) above in combination with physiologically acceptable carriers, in forms such as tablets, capsules, pills, suspensions, solutions, emulsions and suppositories. |
| priorityDate | 1968-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.