http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1229865-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1968-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1229865-A |
| abstract | 1,229,865. Acetals and ketals of glyceryl esters. SCHERICO Ltd. 5 April, 1968 [10 April, 1967], No. 16478/68. Heading C2C. Novel cyclic acetals and ketals of Compounds I in which A is a fused benzene or pyridine ring; R<SP>1</SP> is H, alkyl, CF 3 , alkylthio or one or two halo; R<SP>2</SP> and R<SP>3</SP> are H or alkyl; R<SP>4</SP> is H, halo, OH, NO 2 , alkoxy or alkyl; R<SP>5</SP> is OH, alkyl, alkoxy, CF 3 , NO 2 , NH 2 , H, or mono or di-alkylamino; n is 0, 1, 2 or 3 and the dotted line is an optional bond and their salts are prepared (a) by reacting a compound YCH 2 X by known methods with a compound ZCO-C 6 H 4 -R<SP>1</SP> where X is a cyclic acetal or ketal of an α,# - dihydroxy ethyl group and Y and Z are reactive groups capable of condensing during reaction to leave the bridge X between CH 2 X and -C 6 H 4 R<SP>1</SP>, (b) by reacting a carboxylic acid LCOOH or functional derivative thereof with HOQ where Q is a cyclic acetal or ketal of -CH 2 CHOHCH 2 OH and L is the grouping XI or (c) where an indolinyl or aza indolinyl compound is obtained, by subsequent oxidation to the indole or azaindole compounds. The glyceryl esters themselves may be obtained by ring opening the cyclic acetals or ketals. Certain of these esters are claimed in application 51238/70 which is divided from this application. Intermediates isolated are cyanomethyl (5- methoxy - 2 - methyl - 3 - indolyl) - acetate prepared by reacting the appropriate acetic acid derivative with ClCH 2 CN; acetonyl, phenacyl, carbamoylmethyl and ethoxycarbonyl esters of (5- methoxy - 2 - methyl - 3 - indolyl) - acetate prepared in a similar way to the first-named intermediate; #,y - isopropylidenedioxypropyl (5- methoxy - 2 - methyl - 3 - indolyl) - acetate, prepared by reaction of 2,2 - dimethyl - 4 - hydroxymethyl 1,3 - dioxolan with the first-named intermediate; and cyanomethyl (5 - methoxy - 2 - methyl - 3 - indolyl) α- or # - propionate, butyrate and valerate prepared in a similar manner to the first-named intermediate. Pharmaceutical compositions for oral, rectal, topical or parenteral administration as antiinflammatory agents comprise the novel acetals and ketals in conjunction with suitable excipients. |
| priorityDate | 1967-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.