| abstract |
1,224,530. Indolyl - pyridine derivatives. MILES LABORATORIES Inc. 31 Dec., 1968 [15 Jan., 1968], No. 61988/68. Heading C2C. Novel compounds I in which R is H or 1-4 C alkyl; R<SP>1</SP> is H, 1-4 C alkyl, aralkyl, substituted aralkyl, or aroyl; and R<SP>2</SP> is H, 1-4 C alkoxy or OH and dimers or salts thereof are prepared by reduction of a compound II, where R<SP>1</SP> is not aroyl followed where necessary by reaction with a Grignard reagent and an aroyl halide to give I where R<SP>1</SP> is aroyl and/or salt formation. Compounds II are prepared by cyclization of compounds III followed by reaction with RX where X is halo. Compounds III are prepared by reaction of 3-acetyl-pyridine with the appropriate hydrazine. Pharmaceutical compositions for oral or parenteral administration as antihistamine or antiserotonin agents comprise a compound I together with a suitable carrier. |