http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1217059-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-673 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5456 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-62 |
| filingDate | 1968-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1217059-A |
| titleOfInvention | Improvements in or relating to tetrahydronaphthalenes and the manufacture thereof |
| abstract | 1,217,059. Naphthalene derivatives. UPJOHN CO. 17 Dec., 1968 [2 Jan., 1968], No. 60017/68. Addition to 1,107,016. Heading C2C. [Also in Division A5] Novel, pesticidal and therapeutic compounds I and II (including salts thereof) wherein R is C 1-4 alkoxy or C 3-6 cycloalkoxy, R 1 is H, C 1-4 alkyl or halogen and R 2 is H, halogen, C 1-4 alkyl, C 1-4 alkoxy or C 1-4 alkoxy substituted by -NR 4 R 5 where R 4 and R 5 are C 1-4 alkyl or together with the adjacent N comprise a saturated heterocyclic amine residue having a 5 to 7 membered ring, by dihydroxy - C 2-5 alkyl, by 2 - amino - 1 - hydroxyethyl, by 5 - (2 - thioxooxazolidinyl) -, by 5 - (2 - oxooxazolidinyl) - or by epoxyethyl (compounds II do not include those where R is C 1-4 alkoxy at the 6-position) are obtained: (a) by cyclizing compounds V where R a is H, halogen, C 1-4 alkyl, hydroxy or C 1-4 alkoxy, and, if desired, where R a is OH subsequently alkylating products so obtained, or if desired in the case where products have R 2 as C 1-4 alkoxy substituted by epoxyethyl reacting these with succinimide in the presence of base and then subjecting resulting 2 - succinimide - 1- hydroxyethyl substituted alkoxy compounds to alkaline hydrolysis to afford 2-amino-1- hydroxyethyl alkoxy compounds, then, if further desired, treating the latter compounds with carbon disulphide to afford I wherein R 2 is alkoxy substituted by 5-(2-thioxooxazolidinyl)-, or if desired in the case where R 2 is alkoxy substituted by 2-amino-1-hydroxyethyl reacting with ethyl chloroformate, phosgene or a dialkyl carbonate to afford I wherein R 2 is alkoxy substituted by 5-(2-oxo-oxazolidinyl)- (this process affords I and compounds related to I such that R 2 signifies OH); and (b) by cyclizing compounds IV and reducing resulting 3,4-dihydronaphthalenes III [alkylations and the other optional, subsequent reactions described in process (a) can also be utilized; this process affords II and compounds related to II such that R 2 signifies OH]. The preparation of compounds IV and V is also exemplified as is the preparation of m-methoxybenzyl chloride, m-methoxybenzyltriphenylphosphonium chloride, p - methoxy - # - hydroxy - α - phenyl acrylophenone, an isomeric mixture of 4-(m-methoxyphenyl) - 1 - (p - methoxyphenyl) - 2 - phenyl- 1 - butenones, α - phenyl - # - hydroxyacrylophenone and an isomeric mixture of 1,2-diphenyl- 4 - (m - methoxyphenyl) - 1 - butenones. |
| priorityDate | 1968-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 42.