http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1213571-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-545 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 |
| filingDate | 1968-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a24f50e4d2536a30521e2d25edc6d31c |
| publicationDate | 1970-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1213571-A |
| titleOfInvention | Derivatives of cephalosporanic acid |
| abstract | 1,213,571. Cephalosporins. BRISTOLMYERS CO. 5 Jan., 1968 [5 Jan., 1967], No. 871/68. Heading C2A. The invention comprises an α-pyridylthioacetamido cephalosporanic acid derivative of formula wherein A is H, OH, C 2-8 alkanoyloxy, benzyloxy, a quaternary ammonium radical especially pyridinium, quinolinium, picolinium or lutidinium, or, when taken together with M is a monovalent C-O bond; and M is H, a pharmaceutically acceptable non-toxic cation, an anionic charge when A is a quaternery NH 4 radical or, when taken together with A, is a monovalent C-O bond; and Z is 2,- 3,- or 4- pyridyl. The compounds are prepared by (a) reacting a compound of formula: wherein A and M have the above meaning, with an α-haloacetyl halide of formula in which Hal is chloro, bromo or iodo, or its functional equivalent as an acylating agent, in the presence of a base, to produce an α- haloacetamido compound of formula wherein A and M are as defined above, and (b) reacting the thus-prepared α-haloacetamido compound in the presence of a base with a mercaptan of formula Z-SH wherein Z has the above meaning. Salts are formed with inorganic cations e.g. sodium and potassium, organic amine cations e.g. triethylamine, procaine and N-ethylpiperidine and with inorganic acids e.g. hydrochloric and organic acids e.g. acetic and ascorbic. Typical compounds are 7-[a-(4-pyridylthio)-acetamido]cephalosporanic acid and 3-methyl-7-[α-(4-pyridylthio) acetamido-]-3-cephem-4-carboxylic acid monophosphate. The 3- and 4-pyridyl compounds are more active against gram-negative bacteria than the 2-pyridyl compound. A pharmaceutical composition for parenteral or oral administration to man and animals comprises an α-pyridylthio acetamido cephalosporanic acid of Formula I and a carrier. The compositions may be used for treating mastitis in cattle. The compounds may be used as nutritional supplements in animal feeds. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0953570-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2122603-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6369049-B1 |
| priorityDate | 1967-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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