http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1212966-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 |
| filingDate | 1969-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1212966-A |
| titleOfInvention | 9beta,10alpha-STEROIDS AND A PROCESS FOR THE PREPARATION THEREOF |
| abstract | 1,212,966. 6 - Chloro - 9#,10α - steroids. F. HOFFMANN - LA ROCHE & CO. A.G. 15 May, 1969 [20 May, 1968], No. 24840/69. Heading C2U. The invention comprises compounds of formula wherein R is a 3 - oxo - #<SP>4</SP>, 3 - oxo - #<SP>1</SP>'<SP>4</SP>, 3 - oxo- #<SP>4</SP>'<SP>6</SP>, 3 - oxo - #<SP>1</SP>'<SP>4</SP>'<SP>6</SP>, 3 - "alkoxy" - #<SP>3</SP>'<SP>5</SP>, 3- "alkoxy" - #<SP>4</SP>'<SP>6</SP>, 3 - acyloxy - #<SP>3</SP>'<SP>5</SP>, 3 - acyloxy- #<SP>4</SP>'<SP>6</SP>, 3 - acyloxy - #<SP>2</SP>'<SP>4</SP>'<SP>6</SP> or 3 - hydroxy - #<SP>4</SP>'<SP>6</SP> system, and R<SP>1</SP> is H or acyl. The term "alkoxy" is defined as a C 1-10 aliphatic, cycloaliphatic, aromatic or araliphatic etherified hydroxy group. Compounds I (R=3 - hydroxy - #<SP>4</SP>'<SP>6</SP>; R<SP>1</SP> = H) are prepared by reduction of the corresponding 3,20-diones. Compounds I (R=3À oxo - #<SP>4</SP> or 3 - oxo - #<SP>4</SP>'<SP>6</SP>; R<SP>1</SP> = acyl) are prepared by chlorination of the corresponding 6 - dechloro - 3 - acyloxy - #<SP>3</SP>'<SP>5</SP>, 6 - dechloro - 3- alkoxy - #<SP>3</SP>'<SP>5</SP> or 6 - dechloro - 3 - oxo - #<SP>4</SP>'<SP>6</SP> compounds. Compounds I are interconvertible by oxidation of a 3,20-diol to a 20-ol-3-one, 1,2- and/or 6,7-dehydrogenation, saponification of 20-acylates, esterification, etherification, enol-esterification and enol-etherification. 9#,10α - Pregna - 3,5 - diene - 3,20α - diol diacetate is prepared from 20α - hydroxy - 9#, 10α- pregn - 4 - en - 3 - one by reaction with isopropenyl acetate. Compounds I are stated to possess progestational and antiestrogenic activity and to influence gonadotropin secretion or production, and may be made up with carriers into pharmaceutical compositions for oral and parenteral administration. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3962217-A |
| priorityDate | 1968-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.