http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1206572-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e28032b4dae483384b2f28cb3ee45bc |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 |
| filingDate | 1969-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5593e2ed1ae53afb68e2735169a3ab08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8de6cef7b35048c58531fc4b2cefea2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76486f170deb0ce7adc22d85b8a4be73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53bf99b0a58f1f6d9c375dda2d71f1a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58190469617311f41d4e300cd29f5708 |
| publicationDate | 1970-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1206572-A |
| titleOfInvention | New basically substituted coumarin derivatives and process for the production thereof |
| abstract | 1,206,572. Coumarin derivatives. CASSELLA FARBWERKE MAINKUR A.G. 17 Jan., 1969 [19 Jan., 1968], No. 2868/69. Heading C2C. Novel coumarin derivatives of the formula and pharmaceutically acceptable salts thereof, wherein R is the radical of an aliphatic, cycloaliphatic, araliphatic or aromatic amine or of a 5- or 6-membered heterocyclic nitrogen base free of acyloxy groups, which is bound via a nitrogen atom, R 1 is alkyl or aryl, R 2 is 5,7-, 6,7- or 7,8-positioned alkoxy groups, R 3 is alkoxy, and m is 1, 2 or 3, are obtained (a) by acylating, if desired in the presence of an acidbinding agent, compounds of the formula where R<SP>1</SP> is the same as R above except that the heterocyclic base is free from OH groups, with an alkoxybenzoic acid HOOC.Ph.(R 3 ) m (where Ph is the benzene nucleus) or with a functional derivative thereof, and eliminating by hydrogenation or saponification any protective groups in R<SP>1</SP>; or (b) by reacting, optionally in the presence of an acid-binding agent, a compound of formula (where Hal represents a halogen atom) with an amine of the formula RH. Coumarin derivatives of Formula (II) are obtained by reacting the corresponding amines with the 3-γ-halo-#-hydroxypropyl-coumarins, or with the corresponding 3-(2<SP>1</SP>,3<SP>1</SP>-epoxypropyl)- coumarins. Coumarin derivatives of Formula (IV) are obtained by acylating the corresponding 3-γ- halogen - # - hydroxypropyl - coumarins with an alkoxybenzoic acid HOOC.Ph(R 3 ) m or a functional derivative thereof. Pharmaceutical compositions having activity as coronary dilators comprise a compound of the Formula (I) or a pharmaceutically acceptable salt thereof, together with conventional pharmaceutical carriers, in forms suitable for oral or parenteral administration. |
| priorityDate | 1968-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.