| abstract |
1,203,810. Heterocyclic amino-alcohols. DEUTSCHE GOLD - UND SILBERSCHEIDEANSTALT. 29 Dec., 1967 [30 Dec., 1966 (2)], No. 59037/67. Heading C2C. Novel compounds of formula in which the radicals R 1 -R 4 are H, halo, 1-6C alkyl, aralkyl, phenyl, OH, 1-6C alkoxy, nitro or 1-6C alkoxycarbonyl; R 5 and R 6 are H or methyl; R 7 and R 8 are H, halo, 1-6C alkyl, 1-6C alkoxy or phenyl; X is a mono- or bi-cyclic heterocyclic ring system having 1-4 heteroatoms, 5-6 ring members in each ring and which may contain one or more carbonyl groups and Y is O or a hydrogen atom and a hydroxyl group; their salts and quaternary ammonium derivatives are prepared by (1) reacting II with III in a solvent together with HCHO or a HCHO donor; (2) reacting IV or V with III; or (3) reacting VI with VII in the presence of a base followed in any of (1)-(3) by reduction of the oxo group to the hydroxy group if desired (R 9 and R 10 are 1-6C alkyl, W is halo and V is NH 2 -). |