http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1201127-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c17612db7d98bb4baf5d622f5250492 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-12 |
| filingDate | 1968-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1201127-A |
| titleOfInvention | Derivatives of coumarin |
| abstract | 1,201,127. Coumarin derivatives. LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE. 19 March, 1968 [20 March, 1967], No. 13333/68. Heading C2C. Novel coumarin derivatives selected from 3- amino - 8 - hydroxycoumarin, 3: 7-dihydroxycoumarin, 3: 8 - dihydroxycoumarin, 3-amino- 6: 7 - dihydroxycoumarin, 3: 7: 8 - trihydroxycoumarin, 3:5:7 - trihydroxycoumarin, 3: 6: 7 - trihydroxycoumarin, 3 - ethyl-4: 5: 7- trihydroxycoumarin, 3 - n - propyl - 4: 5: 7 - trihydroxycoumarin, 3 - n - propyl - 4: 7: 8 - trihydroxycoumarin, 3 - n - butyl - 4: 5: 7-trihydroxycoumarin, 3 - n - butyl - 4: 7: 8- trihydroxycoumarin, 3 - sec - butyl - 4: 5: 7- trihydroxycoumarin, 3 - phenyl - 4: 7: 8 - trihydroxycoumarin, 3 - (1<SP>1</SP>- naphthylmethyl)- 4: 5: 7 - trihydroxycoumarin, 3 - (1<SP>1</SP> - naphthylmethyl) - 4: 7:8- trihydroxycoumarin and 3 - (2<SP>1</SP> - # - pyridyl - ethyl) - 4: 5: 7 - trihydroxycoumarin are prepared by a process which comprises: (a) the thermal condensation of a phenol with a substituted malonic ester to give 4-hydroxy-coumarins or (b) hydrolysis, in acidic or alkaline media, and at normal or at elevated pressures of several atmospheres in an autoclave, of the 3-amino derivatives to give 3-hydroxycoumarins. The alkali metal salts are prepared by dissolving the hydroxycoumarin in an alkali metal hydroxide, or by adding the calculated amount of sodium bicarbonate, in the case of the sodium salt. 3 - Acetamido - 6: 7 - cliacetoxycoumarin is prepared by refluxing 2: 4: 5-trihydroxybenzaldehyde, acetyl glycocoll and melted sodium acetate while stirring in acetic anhydride. 3 - Acetamido - 8 - acetoxycoumarin is prepared similarly. Pharmaceutical compositions having hypo-. tensive, spasmolytic and chloheretic activity and containing a compound from the above list, are administered by intravenous injection or orally in association with a suitable pharmaceutical carrier. |
| priorityDate | 1967-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.