http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1199768-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 |
| filingDate | 1967-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1199768-A |
| titleOfInvention | Nitrogen Heterocycles and process for their preparation |
| abstract | 1,199,768. Quinazoline, quinoline and isoquinoline derivatives. CHAS PFIZER & CO. Inc. 27 Oct., 1967 [31 Oct., 1966], No. 49047/67. Heading C2C. The invention comprises compounds of formula and their acid addition salts, wherein A and B are each OH, Me or C 1-5 alkoxy, or one of them is H, or A-B is benzo or C 1-4 alkylenedioxy; R<SP>1</SP> is H, C 1-6 alkyl (possibly halogenated) Ph, PhCH 2 , PhC 2 H 4 or substituted Ph; D<SP>1</SP> and D<SP>2</SP> are each N or one of them is CH; when D<SP>1</SP> and D<SP>2</SP> are both N, Y is NR<SP>2</SP>R<SP>3</SP>, where R<SP>2</SP>, R<SP>3</SP> are each H, alkyl, alkenyl, hydroxyalkyl or cycloalkyl (up to C 6 ), Ph or Ph-C 1-6 -alkyl, or R<SP>2</SP>R<SP>3</SP> complete with the N a saturated 4- or 5- membered ring, or Y is piperidino, morpholino or 4-R<SP>4</SP>-piperazino or -homopiperazino, R<SP>4</SP> being H, alkyl, alkylcarbonyl, MeSO 2 , PhSO 2 , alkoxycarbonyl, alkenyl or alkenyloxycarbonyl (up to C 6 in the alkyl or alkenyl groups), benzoyl, naphthoyl, aryl or aryloxycarbonyl (up to C 10 in the aryl group), or Y is 4-(JCR<SP>13</SP>R<SP>15</SP>CR<SP>5</SP>R<SP>14</SP>OCO)-piperazino or -homopiperazino, where each of R<SP>5</SP>, R<SP>13</SP>, R<SP>14</SP>, R<SP>15</SP> is H, C 1-4 alkyl or CH 2 OH or R<SP>5</SP>-C-C-R<SP>13</SP> is C 6-9 cycloalkyl, and J is H, Cl, Br, OH, C 1-5 acyloxy, C 1-5 alkoxy, C 1-5 acylamido, aryloxy, aroyloxy or aroylamido (up to C 10 in the aryl group), amino (possibly substituted by 1 or 2 C 1-4 alkyl or up to C 10 aryl groups) or a saturated C 4 N-C 7 N ring; when D<SP>1</SP> is CH and D<SP>2</SP> is N, Y is NR<SP>6</SP>R<SP>7</SP> where R<SP>6</SP>, R<SP>7</SP> are each H, C 1-6 alkyl, C 2 H 4 OH, up to C 10 aryl or aryl (up to C 7 )-C 1-3 alkyl (the aryl groups optionally bearing up to 3 substituents, which are halogen or C 1-4 alkoxy), or NR<SP>6</SP>R<SP>7</SP> is a saturated 4- to 8-membered ring, or Y is morpholino, thiamorpholino or 4-X-piperazino [where X is H, C 3-6 alkenylamino, up to C 6 acylamino, (C 1-6 -alkoxy) carbonylamino, (up to C 6 - alkenyloxy) carbonylamino, or arylamino, aroylamino or carbaryloxyamino (up to C 10 in the aryl group)]; or when either D<SP>1</SP> or D<SP>2</SP> is CH and the other is N, Y is 4-(JCR<SP>13</SP>R<SP>15</SP>CR<SP>5</SP>R<SP>14</SP>OCO)- piperazino as defined above. These compounds are prepared by standard methods. Starting materials and intermediates.-Details are given of the preparation of N-carbethoxy-6- aminoveratric acid, 4,5-dimethoxy-N-carbozy - anthranilic anhydride, 6-aminoveratramide, 6- propionamidoveratramide, 2 - ethyl - 6,7 - dimethoxy - 4(3H) - quinazolinone, 2 - ethyl- or methyl - 4 - chloro 6,7 - dimethoxyquinazoline, 6,7 - dimethoxy - 4 - (3H) - quinazolinone, 4 - chloro - 6,7 - dimethoxyquinazoline, phenyl 4 - (6,7 - dimethoxyquinazolin - 4 - yl) piperazine - 1 - thiolcarboxylate, N - carbethoxyhomoveratrylamine, 6,7 dimethoxy - 3,4 - dihydro - 1(2H) - isoquinolinone, 6,7 - dimethoxy - 1(2H) - isoquinolinone, 1 - chloro - 6,7 - dimethoxyisoquinoline and phenyl 4- (6,7 - dimethoxyisoquinolin - 1 - yl) - piperazine - 1-thiolcarboxylate. Therapeutic compositions for inhaling or oral, intravenous or intramuscular administration comprise compounds of the above formula, which are bronchodilators, antihypertensives and muscle relaxants, and inhibit the activity of phosphodiesterase. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2295387-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0021947-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6645969-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6596726-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5439895-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7232903-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5614627-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8367824-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4370328-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6713484-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6057320-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6521620-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4289772-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6084095-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5658902-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6455534-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6358973-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5773444-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006522119-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6265410-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5436233-A |
| priorityDate | 1966-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 77.