http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1198551-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0df514cf393bbf28bd8e42599783b79 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 |
| filingDate | 1968-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_395c68d29ced4674a15917494472fc80 |
| publicationDate | 1970-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1198551-A |
| titleOfInvention | New Nicotinuric Acid Derivatives |
| abstract | 1,198,551. Phenylamino - nicotinuric acid compounds. LABORATOIRES U.P.S.A. 22 Jan., 1969 [22 Jan., 1968; 10 July, 1968], Nos. 3273/68 and 32988/68. Heading C2C. Novel nicotinuric acid derivatives of the formula and their non-toxic, pharmaceutically acceptable salts, esters and amides, wherein R<SP>1</SP> is H, CH 3 or C 2 H 5 , R<SP>11</SP> is H, CH 3 , C 2 H 5 or CH 3 SCH 2 - CH 2 , and R 1 and R 2 may be identical or different and each represents H, halogen, CH 3 , C 2 H 5 , CH 3 O, C 2 H 5 O or trihalogenomethyl, especially CF 3 , are obtained by contacting an acid halide of the formula in which Hal represents a halogen atom, either (a) with an alkali metal salt of a glycine derivative of formula in which M is alkali metal, in aqueous medium, and converting the resulting salt to the free acid by acidification, or (b) with an alkyl ester of glycine of formula in which R 3 is CH 3 or C 2 H 5 , and saponifying the resulting ester in alkaline medium to yield the desired acid. Pharmaceutical compositions, useful as anti-inflammation, antalgic and fibrinolytic agents, comprise a derivative of nicotinuric acid of Formula (I) above, or salt, ester or amide thereof, and a non-toxic pharmaceutically acceptable carrier or vehicle, exemplified in the form of gelatin-coated pills, suppositories, ointment and aqueous solution. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2002363174-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03037869-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7183288-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-007578-B1 |
| priorityDate | 1968-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.