| abstract |
1,189,973. Pyrimidine nucleosides. DEUTSCHE AKADEMIE DER WISSENSCHAFTEN ZU BERLIN. 14 Feb., 1969, No. 8107/69. Heading C2C. Novel, cytoatatically active compounds I wherein X is oxygen, sulphur or imino and R is hydrogen, halogen, hydroxy, mercapto or unsubstituted or substituted alkyl, are obtained by reacting a corresponding pyrimidine nucleoside, appropriately substituted on the oxygen of the 3<SP>1</SP>-hydroxy group, with a fluoronation agent. 2<SP>1</SP>,3<SP>1</SP>-Didehydro-3<SP>1</SP>-desoxy-thymidine is prepared by treating 1-(2<SP>1</SP>,3<SP>1</SP>-didesoxy-3<SP>1</SP>-fluoro- #-D-pentofuranosyl)-thymine (a compound of the invention) with aqueous alcoholic sodium hydroxide solution. |