http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1181366-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9af917dd1e6e93fa16bca5901dcc6f2f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-408 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-40 |
| filingDate | 1966-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a719f36ed0d6490007339788a7d74627 |
| publicationDate | 1970-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1181366-A |
| titleOfInvention | Succinimide Derivatives |
| abstract | 1,181,366. Succinimide derivatives. ED GEISTLICH SOHNE A.G. FUR CHEMISCHE INDUSTRIE. 21 Dec., 1967 [23 Dec., 1966], No. 57731/66. Heading C2C. Novel compounds I (including salts with bases) wherein R represents an aryl or araliphatic group substituted in the aromatic ring with at least one sulphamoyl or sulphonamido group (including the group -SO 2 . heterocyclic, i.e. the nitrogen atom of the sulphonamido group may comprise a heterocyclic ring, and the group .wherein the chain -CO.NH.SO 2 - is joined at its ends to the same benzene ring; R may carry other substituents in addition to sulphonamido) R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP> and R<SP>4</SP>, which may be the same or different, signify hydrogen atoms, C 1-5 alkyl groups or aryl groups, at least one of the substituents R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP> and R<SP>4</SP> being an aryl group (may carry the usual substituents including methylenedioxy), are prepared: (a) by reacting an amine, RNH 2 , with an acid, HOOC.CR<SP>1</SP>R<SP>2</SP>.CR<SP>3</SP>R<SP>4</SP>.COOH or a reactive derivative thereof, e.g. the anhydride, and, if necessary, converting substituents attached to R into other substituents after the cyclization; or (b) by reacting compounds related to those illustrated above with one or more reagents suitable for the introduction of a sulphamoyl or sulphonamido group. 1 - N - [α - (p - Chlorosulphonylphenyl)- α - methyl - succinimido] - 4 - chlorosulphonylbenzene is obtained by the interaction of chlorosulphonic acid and α-phenyl-α-methyl-succinimido-benzene. 1 - N - [α - (p - Chlorosulphonylphenyl) - α - methyl - succinimido] - 4 - sulphonamidobenzene is obtained by the interaction of chlorosulphonic acid and α-phenyl-α-methyl-succinimido-4-sulphonamidobenzene. Pharmaceutical preparations useful for the treatment of epilepsy and having diuretic activity contain as active ingredient compounds I and may be made up in the form of tablets, dragees, capsules, lozenges, suppositories, ampoules for injection, or solutions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5142062-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4177192-A |
| priorityDate | 1966-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.