http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1179479-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7f1a4cbdd4777314999fe906c1ca45d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 |
| filingDate | 1967-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bb3d40681627034b76c36ca5f980409 |
| publicationDate | 1970-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1179479-A |
| titleOfInvention | Derivatives of Thebaine |
| abstract | 1,179,479. 6,14-Endoethenonorthebaine derivatives. RECKITT & SONS Ltd. 13 June, 1968 [20 June, 1967], No. 28357/67. Heading C2C. The invention comprises compounds of the Formula I:- wherein R<SP>1</SP> represents a cyano or ethoxy carbonyl group; R<SP>2</SP> represents a C 1-3 alkyl, acetoxy or ethoxycarbonyl group or a chlorine or bromine atom with the proviso that when R<SP>2</SP> represents a C 1-3 alkyl group, R<SP>1</SP> represents a cyano group and when R<SP>2</SP> represents an acetoxy group, R<SP>1</SP> represents an ethoxycarbonyl group; and R<SP>3</SP> represents a hydrogen atom or C 1-8 alkyl, C 2-8 alkenyl or C 2-8 alkynyl group or a C 4-7 alicyclic substituted methyl group; and pharmaceutically acceptable salts thereof and their preparation; where R<SP>3</SP> represents other than a hydrogen atom, by reacting the appropriately N-substituted northebaine with a dienophile of the formula CH 2 = CR<SP>1</SP>R<SP>3</SP>, where R<SP>3</SP> represents a hydrogen atom, by treating a compound of the Formula I wherein R<SP>3</SP> represents a methyl group with a di-(C 1-4 alkyl) azodicarboxylate followed by treatment with a mineral acid, and where R<SP>3</SP> represents neither a hydrogen atom nor a methyl group, by reacting a compound of the Formula I wherein R<SP>3</SP> represents a hydrogen atom with a halide of the formula R<SP>3</SP>X where X represents a halogen atom and optionally converting any product into an acid addition salt thereof. Therapeutic compositions with analgesic, sedative and antitussive activity and depressant effects on the peripheral autonomic nerve function, for oral administration, comprise compounds of the invention with a carrier. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2062896-A1 |
| priorityDate | 1967-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.