http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1178329-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0f72c66096c79f62800a395826ee550 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-38 |
| filingDate | 1967-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1178329-A |
| titleOfInvention | N-[delta-(6-Purinylthio) Valeryl] Amino Acids and derivatives thereof, and a method of producing the same |
| abstract | 1,178,329. N - [# - (6 - Purinylthio) - valeryl]- amino acid derivatives. SPOFA, UNITED PHARMACEUTICAL WORKS. 14 June, 1967 [1 July, 1966], No. 27367/67. Heading C2C. Novel N - [8 - (6 - purinylthio) - valeryl]- amino acid derivatives of the general formula wherein n is 0 or an integer from 1 to 5; R is a C 1-8 straight or branch chain alkoxy or hydroxy group or a residue of a peptidically bound amino acid or dipeptide having the carboxyl group(s) either free or esterified with an alcohol containing a straight or branched carbon chain with 1-7 carbon atoms, wherein said residues, so far as they contain an asymmetric carbon atom, can be optically active or racemic; Y is hydrogen, or a C 1-5 alkyl, phenyl, benzyl, α-hydroxybenzyl, 3-indolyl, 3-indolylmethyl, -CH 2 OH, -CH 2 SH, -(CH 2 ) m SCH 3 , -(CH 2 ) m COR 1 , or group, wherein m is an integer from 1 to 3 and R 1 is an alkoxy group with a straight or branched carbon chain having 1-8 carbon atoms, are prepared, when R is a C 1-8 alkoxy group, by condensation of a 6-(4-carboxybutyl)-thiopurine derivative and an amino acid ester of the respective general formulµ wherein X is chlorine or -N 3 and R 2 is an alkoxy group containing a straight or branched carbon chain with 1-8 carbon atoms; or, when R is a hydroxy group, by saponification with alkali of the resulting N-[#-(6-purinylthio)-valeryl]- amino acid derivative of the first general formula above wherein R is a C 1-8 alkoxy group; or, when R 1 is a residue of a peptidically bound amino acid or dipeptide, by reaction of said resulting amino acid derivative with hydrazine hydrate to form the corresponding N-[#-(6- purinylthio)-valeryl]-amino acid hydrazide, reaction of said hydrazide with nitrous acid to form the corresponding N-[#-(6-purinylthio)- valeryl]-amino acid azide and subsequent condensation with an amino acid ester of the third general formula above to give an ester of a dipeptide of the first general formula above, which can be alkali-saponified to the corresponding free acid and the latter optionally converted to a tripeptide ester of the first general formula above by reaction with an amino acid ester of the third general formula above in the presence of N,N<SP>1</SP>-dicyclohexyl carbodiimide, which ester can in turn be alkali-saponified to the corresponding free acid. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4011221-A |
| priorityDate | 1966-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.