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filingDate 1966-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1970-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1177648-A
titleOfInvention 09-Substituted-6beta,19- and 11beta,19-Steroid Oxides
abstract 1,177,648. Medicines comprising steroids. RESEARCH INSTITUTE FOR MEDICINE & CHEMISTRY, Inc. 13 Dec., 1966 [17 Dec., 1965], No. 55874/66. Heading A5B. [Also in Division C2] Pharmaceutical compositions comprise steroids of the skeletal formula: (wherein Y is oxo, OH or acyloxy; Z is OH, esterified OH, etherified OH or F; R is an oxygen atom which is also joined to the 6- or 11-position; either R<SP>1</SP> is optionally ketalised acetyl or monohaloacetyl and R<SP>2</SP> is H, OH or acyloxy, or R<SP>1</SP> is OH and R<SP>2</SP> is an optionally halo-substituted aliphatic hydrocarbon group; and R<SP>3</SP> is a substituent eliminatable with a hydrogen atom at the 4-position, or represents a carbon-carbon bond joined to the 4-position), and/or 3-ketals of such compounds wherein Y is OXO, together with a pharmaceutical carrier or excipient. The active ingredients are stated to possess antifertility and aldosteroneblocking activities. Administration may be oral, parenteral or rectal. The compositions may additionally include estrogenic or proestrogenic agents, progestational agents, carbonic anhydrase inhibitors (e.g. dichlorophenamide or acetazolamide derivatives), thiazide diuretics (e.g. trichlormethazide), xanthene diuretics, ethacrynic acid derivatvies, and/or triamterene derivatives. Reference has been directed by the Comptroller to Specification 1,046,242.
priorityDate 1965-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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