http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1164671-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7f1a4cbdd4777314999fe906c1ca45d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 |
| filingDate | 1967-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_690d90930cbaae9a8a5b992bb72694fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_990d2f8bdc5633cf0267f6bbbc88f950 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bb3d40681627034b76c36ca5f980409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79b8088a89f5ef3cc7db35ef684a047b |
| publicationDate | 1969-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1164671-A |
| titleOfInvention | Novel Derivatives of Thebaine and Oripavine to their Salts, and to processes for their preparation |
| abstract | 1,164,671. Thebaine and oripavine derivatives. RECKITT & SONS Ltd. 26 March, 1968 [31 March, 1967], No. 14755/67. Heading C2C. Novel thebaine and oripavine derivatives of the general formula wherein Y represents the ethero (-CH = CH-) or the ethano (-CH 2 -CH 2 -) group, Q represents one of the radicals R represents a methyl group or a hydrogen atom, R<SP>1</SP> represents a hydrogen atom, an alkyl or alkenyl group of up to 3 carbon atoms, a phenyl or a tolyl group, R<SP>2</SP> represents a cycloalkyl group of 5 to 7 carbon atoms, an alkyl or alkenyl group of up to 8 carbon atoms, a benzyl or a phenethyl group, R<SP>3</SP> represents an alkyl group of up to 5 carbon atoms, a cycloalkylmethyl of 4 to 6 carbon atoms, an allyl, methylallyl, dimethylallyl or crotyl group; R<SP>4</SP> represents an alkyl group of up to 5 carbon atoms, and their acid addition salts; are prepared by dehydrogenating compounds of general formula wherein R, R<SP>3</SP>, Q and Y are as defined above. The above compounds where Q is the group may also be prepared by treating a compound of general formula (A) wherein Y, R, R<SP>1</SP>, R<SP>2</SP> and R<SP>3</SP> are as defined above and Q is the group with respectively a Grignard reagent R<SP>2</SP>MgX or an alkyl lithium, LiR<SP>2</SP>; or with a Grignard reagent R<SP>1</SP>MgX or an alkyl lithium LiR<SP>1</SP>, where X is a halogen atom. The above compounds where Q is the group may also be prepared by treating a compound of general Formula (A), wherein Y, R, R<SP>1</SP>, R<SP>2</SP> and R<SP>3</SP> are as defined above and Q is the group with lithium aluminium hydride or aluminium isopropoxide. The above compounds where Q is the group (where R<SP>1</SP>=R 2 ) may also be prepared by treating a compound of general Formula (A) wherein Y, R, R<SP>4</SP>, R<SP>1</SP> and R<SP>3</SP> are as defined above and Q is the group with two moles of a Grignard reagent R<SP>1</SP>MgX or an alkyl lithium LiR<SP>1</SP>, wherein X is a halogen atom. Pharmaceutical compositions containing the above compounds where Q = having analgesic and antitussive activity may be administered orally or parenterally. |
| priorityDate | 1967-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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