http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1160933-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_249d88916b29a57a878f8702290b5d33 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-52 |
| filingDate | 1967-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7e5437c38cd246da56835078cccc711 |
| publicationDate | 1969-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1160933-A |
| titleOfInvention | Improvements in or relating to New Derivatives of 5-Cycloalkanespiro Oxazolidines |
| abstract | 1,160,933. 5 - Cycloalkanespiro oxazolidine derivatives. LABORATOIRES JACQUES LOGEAIS. 31 May, 1968 [13 June, 1967], No. 27238/67. Heading C2C. Novel 5-cycloalkanespiro oxazolidines having the general formula (I):- wherein n is an integer equal to 4, 5 or 6; R 1 is a straight or branched chain alkyl radical, a cycloalkyl radical, an aryl radical (optionally substituted with one or two halogen, hydroxy, alkyl, alkoxy, nitro, amino, alkylamino or -O-CH 2 -O groups), an aralkyl radical (optionally nuclearly substituted with one of the aforesaid substituents), a furyl, thienyl or pyridyl radical; R 2 is a straight or branched chain alkyl radical, or an aralkyl radical (optionally nuclearly substituted with one of the aforesaid substituents); R 3 is a straight or branched chain alkyl radical, an aryl radical (optionally substituted by a halogen, alkyl, alkoxy, or -N(CH 3 ) 2 group), or R 3 , together with R 2 , the carbon atom carrying R 3 and N forms a saturated ring having 4 or 5 carbon atoms; R 4 is hydrogen or a lower alkyl group having 1 to 6 carbon atoms; or their acid addition salts are prepared by reacting an aldehyde of the formula R 1 -CHO with an amine of the Formula (II): The reaction is preferably carried out under reflux in an anhydrous solvent such as benzene or toluene, the water formed being removed by means of a dehydrating agent such as driesite or p-toluene sulphonic acid. On completion of the reaction, the desired product may be separated from the reaction medium by evaporating the solvent under reduced pressure. The product may be purified with ether. Pharmaceutical compositions having coronary vasodilating properties which are of particular value therapeutically for the treatment of myocardial infarction and of angina pectoris and containing a compound defined above having the Formula (I) or their acid addition salts are administered parenterally or orally in association with a pharmaceutically administrable vehicle or excipient. |
| priorityDate | 1967-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.