http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1160072-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B02C17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B02C17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B02C21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-26 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B02C21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B02C17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B02C17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B23-14 |
| filingDate | 1966-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1160072-A |
| titleOfInvention | 2(3-Amino-6-Halopyrazinamidino)-2-Imidazolines and Pharmaceutical Compositions Containing them |
| abstract | 1,160,072. 2 - (3 - Amino - 6 - halopyrazinamidino) - 2 - imidazolines. MERCK & CO. Inc. 28 Sept., 1966 [4 Oct., 1965], No. 43402/66. Heading C2C. Novel 2 - (3 - amino - 6 - halopyrazinamidino)- 2-imidazoline compounds of the formula where X is H, Cl, Br, C 1-6 alkyl, mononucleararyl-substituted C 1-6 alkyl, C 1-6 alkoxy, mononuclear-aryl-substituted C 1-6 alkoxy, C 1-6 alkylthio, mononuclear-aryl-substituted C 1-6 alkylthio, mononuclear-aryl, amino R<SP>1</SP>R<SP>2</SP>N-, where each R<SP>1</SP> and R<SP>2</SP> is H, C 1-6 alkoxy mononuclear aryl, C 1-6 alkyl, C 3-6 alicyclic, C 1-6 alkyl substituted by halo, hydroxy, alkoxy, alicyclic, mononuclear aryl, (C 1-6 alkyl)-substituted aryl halo-substituted aryl, di-(C 1-6 alkyl) amino or a heterocyclic radical (e.g. furyl or pyridyl) or R<SP>1</SP>R<SP>2</SP>N- has the structure -N(CH 2 ) n , where n is 4, 5 or 6; and Y is Cl or Br, are obtained by reacting a 3-amino-5-X-6-Y-pyrazinonitrile, an alkyl 3 - amino - 5 - X - 6 - Y - pyrazinthioimidate or an alkyl 3-amino-5-X-6-Y-pyrazinimidate acid-addition salt with 2-amino-2- imidazoline. The alkyl 3-amino-5-X-6-Y-pyrazinimidate- HCl can be obtained from the 3-amino-5X-6-Y- pyrazinonitrile and an alcohol, e.g. ethanol, in the presence of HCl at ambient temperature. The 3 - amino - 5 - X - 6 - Y - pyrazinonitrile starting materials are described in Specification 1,149,639. Pharmaceutical compositions, having diuretic and saluretic properties, comprise a compound of Formula I and an inert diluent, carrier or coating, in forms suitable for oral or parenteral administration. |
| priorityDate | 1965-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.