http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1158962-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56ee5285e8e8edccb061046ff20da7a6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-10 |
| filingDate | 1967-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1158962-A |
| titleOfInvention | Process for the Preparation of Hexose-1,6- and Pentose-1,5-Diphosphates. |
| abstract | 1,158,962. Preparing hexose-1,6- and pentose-1,5-diphosphates. BOEHRINGER MANNHEIM G.m.b.H. 13 June, 1967 [15 June, 1966], No. 27169/67. Heading C2C. Hexose-1,6- and pentose- 1 ,5-diphosphates are obtained by acylating a hexose-6-mono-phosphate or a pentose-5-monophosphate with an excess of an acylating agent, removing the excess of acylating agent, melting the residue, with gentle warming, with an excess of anhydrous ortho- and/or pyro-phosphoric acid, adding an alkaline lye to render the reaction product alkaline and then separating the desired diphosphate. The acylating agent may be a C 1 -C 4 fatty acid derivative, e.g. acetic acid or acetyl chloride and the acylation is preferably carried out at 0 to 120 C. in the presence of a condensation catalyst, e.g. zinc chloride, perchloric acid, pyridine or sodium acetate and an inert solvent may be present. The alkaline lye may be. an aqueous or alcoholic lye, and may be, e.g. ammonia or lithium hydroxide or an alcoholic solution of NaOH or KOH, a methanolic solution of NaOH being preferred. When alcoholic lye is used the corresponding salts of the sugar diphosphoric acids and of the ortho- and/or pyrophosphoric acids precipitate out and can be easily separated, e.g. by filtration or centrifugation and can be further purified, e.g. by dissolving the precipitated salts in hot water, adjusting the pH to 9À0, cooling to 0 C. to crystallize out the major portion of the orthophosphate as the dodecahydrate and removing the remainder in the form of magnesium ammonium phosphate by adding a water-soluble magnesium salt and then adding ammonia. The sugar diphosphate can then be separated from the residue, e.g. as the cyclohexyl ammonium salt. Specified sugar monophosphates for use as starting materials are glucose-, galactose- and mannose- 6-phosphates and arabinose-, ribose and xylose- 5-phosphates. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6310042-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9609310-A1 |
| priorityDate | 1966-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.