http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1155936-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F16L9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F16L9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-62 |
| filingDate | 1967-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1155936-A |
| titleOfInvention | Novel Sulphonamides and a Process for the Manufacture thereof |
| abstract | 1,155,936. Sulphonyl-ureas. F. HOFFMANN-LA ROCHE & CO. A.G. 27 Oct., 1967 [28 Oct., 1966; 24 April, 1967; 17 July, 1967], No. 48920/67. Heading C2C. Novel terpenic sulphonyl-ureas (and salts thereof with bases) of the general Formula (I) wherein R stands for a hydrogen atom or a methyl group, R 1 stands for a hydrogen atom, and R 2 stands for a hydroxy group or R 1 and R 2 together stand for an OXO or ketalized OXO group and R 3 stands for a phenyl group which may be substituted by halogen, alkyl, alkoxy, alkylthio, amino, acetyl, acylamino or diacylamino (e.g. phthalimido), a benzamidoethylphenyl group which is substituted by alkoxy and/or halogen, or a 5- or 6-membered N-containing heterocyclic group linked through a N-atom, are prepared: (a) by reacting a reactive derivative of a sulphonylcarbamic acid, R 3 SO 2 NHCOOH, or a sulphonylisocyanate, R 3 SO 2 -N=C=O, with an intermediate. bicyclic amine of general Formula (II) (also described in salt form; obtained by reduction of the related isonitroso compound); (b) by reacting a salt of the amide of a sulphonic acid of the general formula, R 3 SO 3 H with an appropriate bicyclic isocyanate in which R 1 together with R 2 stands for the OXO group or a ketal thereof; or (c) by treating an intermediate N-substituted oxazolidinone of the general Formula (III) (obtained by reacting the unsubstituted compound with a reactive derivative of an R 3 -sulphonylcarbamic acid or with an R 3 -sulphonylisocyanate) with an alkali metal hydroxide and, if desired, reducing the ring- located keto group if present in the reaction product of embodiment (a) or (b) and separating the isomers obtained thereby or, if desired, oxidizing any product which carries a hydroxy group or, if desired, saponifying any product which carries a ketalized OXO group. 3 - Isonitroso - D,L - norcamphor is obtained by reacting D,L-norcamphor with amyl nitrite in the presence of sodium tert-butylate. Pharmaceutical preparations showing hypoglycaemic activity contain as active ingredient the above novel compounds and administration is orally. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9118890-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11130731-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11465992-B2 |
| priorityDate | 1966-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.