http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1153346-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-94 |
| filingDate | 1966-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1153346-A |
| titleOfInvention | Nitroimidazole Derivatives and their preparation and use |
| abstract | 1,153,346. Nitroimidazole derivatives. MERCK & CO. Inc. 4 July, 1966 [7 July, 1965; 18 May, 1966], No. 29844/66. Heading C2C. Novel compounds of formula (wherein R 1 is alkyl optionally substituted by oxo, alkanoyloxy, phenylalkanoyloxy, benzoyloxy, alkoxy, phenylalkoxy, alkoxycarbonyl, phenalkoxycarbonyl, alkylcarbamoyl, phenylalkylcarbamoyl, phenylcarbamoyl, carbamoyl, cyano, alkylthio, phenylthio, phenylalkylthio, alkylsulphinyl, phenylalkylsulphinyl, phenylsulphinyl, alkylsulphonyl, phenylalkylsulphonyl, phenylsulphonyl, carbamoyloxy, halo or alkenyl; Q is alkylene, alkylidene, alkenylene or phenylalkylene; each of A and M is oxygen or sulphur; W is nitro, cyano, phenyl or hydrogen, and P is hydrogen or nitro provided that one of the groups W and P is nitro; in which all the alkyl, alkoxy, alkanoyl, alkylene, alkylidene and alkenylene radicals mentioned above contain 1-5 carbon atoms) are prepared by reaction of a phenyl haloformate or phenyl thionohaloformate with an appropriate 2- (hydroxy- or mercapto-hydrocarbyl)-imidazole in the presence of an acid-binding agent and a solvent. The compounds of Formula I may be converted into compounds of formula (wherein R<SP>1</SP> 1 is C 1-5 hydroxyalkyl, C 2-6 carboxyalkyl, or any value defined for R 1 above, and each of R 3 and R 4 is hydrogen, phenyl, pfluorophenyl, hydroxy, alkoxy, phenalkoxy, phenoxy; alkyl optionally substituted by halo, hydroxy, alkoxy, alkoxycarbonyl, phenyl-alkoxycarbonyl, alkanoyloxy, phenylalkanoyloxy, carbamoyl, carbamoyloxy, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, phenylsulphamoyl, diphenylsulphamoyl, phenylalkylsulphamoyl, dibenzylsulphamoyl, alkylthio, phenylalkylthio, thionocarbamoyl, amino, dialkylamino, diphenylalkylamino, heterocyclylalkyl containing at least one N atom in the ring, meroapto, benzoyloxy or phenyl; or amino optionally substituted by carbamoyl, lower alkylidene, phenylalkylidene, alkanoyl, phenylalkanoyl or benzoyl; or wherein -NR 3 R 4 is a heterocycloalkyl radical) by reaction with a compound of formula HNR 3 R 4 in a solvent, and if required hydrolysing any acyloxy or hydrocarbonoxycarbonyl substituent on R 1 to a hydroxy or carboxy substituent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3696116-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3987053-A |
| priorityDate | 1965-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.