http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1147626-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5deddb47ccaab1d4da2aacc344dd8717 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G03C1-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G03C1-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 1967-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adc49a05d4f5f59fc42b287b87ca9a4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c8dd0c5567086d0e8739c1109e86050 |
| publicationDate | 1969-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1147626-A |
| titleOfInvention | Thiazole derivatives |
| abstract | 1,147,626. Thiazoles. JOHN WYETH & BRO. Ltd. 21 May, 1968 [7 June, 1967], No. 26262/67. Heading C2C. Novel compounds of formulµ and acid addition salts thereof in which R<SP>1</SP> and R<SP>2</SP> are the same or different and are substituted or unsubstituted aryl of heteroaryl groups and R<SP>3</SP> is a C 2-6 straight or branched chain aliphatic acid radical which is attached to the thiazole ring by a carbon atom of the aliphatic chain or a salt, ester, amide, thioamide or hydroxamic acid derivative thereof are prepared by reacting an α-haloketone with a thioamide R<SP>1</SP>-CS-NH 2 or by reacting an α-halo-ketone with a thiomide R<SP>4</SP>-CS-NH 2 wherein R<SP>4</SP> is a C 2-6 aliphatic carboxylic acid radical or a derivative convertable thereto and if necessary converting R<SP>4</SP> to R<SP>3</SP>. Intermediates isolated are ethyl 4-bromo-4- phenyl-acetoacetate from the bromination of ethyl 4-phenyl-acetoacetate; 2-benzoyloxymethyl- 4,5 - diphenylthiazole from α-bromodeoxybenzoin and benzoyloxythioacetamide; 2 - hydroxymethyl - 4,5 - diphenylthiazole by hydrolysis of the former intermediate; 2- chloromethyl - 4,5 - diphenylthiazole by treatment of the last-named intermediate with phosphorus oxychloride; diethyl 4,5-diphenylthiazol-2-yl-malonate by reaction of the lastnamed intermediate with sodium dimethyl malonate; its corresponding acid by hydrolysis of the ester; and ethyl 4-bromo-4-(p-chlorophenyl) acetoacetate by bromination of the corresponding acetoacetate. Pharmaceutical compositions comprise a novel compound of the invention together with a suitable carrier and may be administered orally or parenterally. They possess anti-inflammatory properties and are non-ulcerogenic. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02083111-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0368592-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5182402-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5084083-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7759373-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02083111-A2 |
| priorityDate | 1966-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.