http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1146053-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1966-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1146053-A |
| titleOfInvention | Improvements in or relating to novel steroids and the manufacture thereof |
| abstract | 1,146,053. Steroids. UPJOHN CO. 6 April, 1966 [7 April, 1965], No. 15371/66. Heading C2U. The invention comprises a compound of the formula wherein R 1 and R 2 are H or CH 3 , Y<SP>1</SP> is C=O, in which n is 1 or 2 and R is H or (C 1 -C 6 ) alkyl; Z is H or the acyl radical of a (C 1 -C 12 ) hydrocarbon carboxylic acid, and Q is H, (C 1 -C 12 ) alkyl; or -C#CA, -CH=CHA or -CH2CH 2 A, where A is H, (C 1 -C 12 ) alkyl, Cl, Br, or CF 3 ; except that when R 2 is H and Y<SP>1</SP> is C = O then Z can only be the acyl radical of a (C 1 -C 12 ) hydrocarbon carboxylic acid, and Q can only be -C#CX, where X is Cl or Br a process for the production of a compound wherein R 1 , Z and Q are as defined above, by methylation at the 2α-position, the corresponding 2-unsubstituted compound, a process for the production of compounds of the formulµ wherein Y is C = O, R 1 and R 2 are H or CH 3 , Z and A are as defined above except that when R 2 is H and Y is C = O, Z must be the acyl radical of a (C 1 -C 12 ) organic carboxylic acid and A must be Cl or Br, by subjecting to alkynation at the 17α-position the corresponding 17-keto compound if necessary protecting the 3-keto group by ketalization followed by subsequent hydrolysis and a process for the production of a compound of the formula wherein R 1 , R 2 , Z and A are as defined above by subjecting to alkynation in 17α-position a corresponding compound of the formula wherein R 1 and R 2 are as defined above and R is -O alkyl of 1-5 carbon atoms or a cyclic amino radical of the formula wherein n is 4 or 5 and hydrolysing the resultant compound at the 3-position to yield the desired 3-keto compound. Pharmaceutical compositions containing the above compounds of improved anabolic/androgenic ratio which may also possess anti-fertility, anti-androgenic and anti-estrogenic activities may be administered orally or parenterally. |
| priorityDate | 1965-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419528439 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID222 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456171974 |
Total number of triples: 17.