http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1131534-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-44 |
| filingDate | 1967-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1131534-A |
| titleOfInvention | Novel piperidino-butyrophenones and a process for the manufacture thereof |
| abstract | 1,131,534. Piperidino-butyrophenones. F. HOFFMANN-LA ROCHE & CO., A.G. 10 July, 1967 [11 July, 1966], No. 31596/67. Heading C2C. Novel compounds of the formula and their acid addition and quaternary salts where R 1 is C 1-7 alkyl, C 3-6 cycloalkyl, (C 3-6 cycloalkyl) - (C 1-7 alkyl), C 1-7 hydroxyalkyl or (C 1-7 alkoxy)C 1-7 alkyl, R 2 is acyl and X is halogen are prepared by reacting a 4-hydroxy piperidine of the formula with a compound of the formula where Y is a leaving group and then optionally subjecting the (C 1-7 alkoxy) C 1-7 alkyl group, if present, to ether cleavage to give a C 1-7 hydroxyalkyl group and optionally acylating the hydroxy group. The 4-hydroxypiperidines are made (a) by hydrogenating 4-hydroxy-4-phenylpiperidine in the presence of platinum oxide to give 4- cyclohexyl - 4 - hydroxypiperidine, (b) by reacting an alkyl lithium or cyclopropyl lithium with 1-benzyl-4-piperidone to give a 4-alkyl-1- benzyl - 4 - hydrorypiperidine or 1 - benzyl - 4 - cyclopropyl-4-hydroxypiperidine and then hydrogenating these compounds in the presence of palladium on charcoal to give 4-alkyl-4-hydroxypiperidine or 4 - cyclopropyl - 4 - hydroxypiperidine and (c) 1-benzy]-4-[3-(1,1-dimethylpropoxy)-propyl]-4-hydroxypiperidine is hydrogenated in the presence of palladium on charcoal to give 4-[3-(1,1-dimethylpropory)-propyl]- 4-hydroxypiperidine. Pharmaceutical compositions effective as analgesics, sedatives, antipyretics and anti-inflammatory agents comprise one of the novel compounds of the above formula or an acid addition or quaternary salt as the active ingredient and a carrier and are administered as tablets, dragĂes, capsules, solutions, suspensions or emulsions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4855307-A |
| priorityDate | 1966-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.