http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1128938-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bf2ba08adb8ed810fa2aafc13dea308 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-12 |
| filingDate | 1967-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1128938-A |
| titleOfInvention | New tricyclic aminoalkyl derivatives |
| abstract | 1,128,938. Tricyclic aminoalkyl derivatives. C. F. BOEHRINGER & SOEHNE G.m.b.H. 19 July, 1967 [21 July, 1966], No. 33103/67. Heading C2C. Novel compounds (and salts thereof) possessing cardiac and circulatory actions of the general formula wherein X is an oxygen or sulphur atom, a saturated or unsaturated, straight-chain or branched alkylene radical with up to 3 carbons, an oxaethylene thiaethylene or thiapropylene radical or a valency bond, R 1 is a hydrogen or halogen atom or an alkyl, alkoxy or -CF 3 radical, R 2 is an hydrogen atom or a hydroxyl group, R 3 is a hydrogen atom or, together with R 2 , represents a further valency bond, R 4 and R 5 , which may be the same or different, are hydrogen atoms or C 1 to C 3 alkyl radicals, A is an alkylene radical which is substituted by an optionally acylated hydroxyl group, Y is an oxygen or sulphur atom or an optionally alkylated imino group and Z is an aryl, aralkyl, cycloalkyl or cycloalkyl-alkyl radical which may be substituted by halogen atoms, hydroxyl, nitro or amino groups or alkoxy, aralkoxy, alkyl, -CF 3 , alkylamino or alkylsulphonyl groups, are prepared: (a) by reacting amines of the general formula with intermediate epoxides of general formula in which A<SP>11</SP> represents an alkylene radical which contains two carbon atoms less than A, or with the corresponding halohydrins; or (b) condensing amines of general formula R 5 NHAYZ with compounds of general formula in which U represents a formyl radical or a reactive group derived from a carboxy group and reducing the intermediates obtained and if desired subsequently alkylating. The above epoxides are obtained by the interaction of the compound H-Y-Z and epichlorhydrin in the presence of boron trifluoride etherate and thereafter treating with powdered sodium hydroxide or by interacting epichlorhydrin and the compound Na-YZ. The rearrangement of 11 -hydroxy-11 -ethynyl- 6, 11 - dihydro - dibenzo - [b,e] - oxepine (obtained by the reaction of 6,11-dihydro-dibenzo-[b,e]- oxepin-11-one with acetylene and sodium in liquid ammonia) in an aqueous alcoholic solution of sulphuric acid affords 6,11-dihydrodibenzo - [b,e] - oxepin - 11 - ylidene - acetaldehyde. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4835179-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2339396-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4070373-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4835156-A |
| priorityDate | 1966-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.