http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1125455-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-06 |
| filingDate | 1966-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1125455-A |
| titleOfInvention | Novel substituted azabicyclo octanes and nonanes and manufacture thereof |
| abstract | 1,125,455. Substituted azabicyclooctanes and nonanes; pencillin salts. UPJOHN CO. 25 March, 1966 [28 April, 1965], No. 13336/66. Headings C2A and C2C. Novel compounds of the formula wherein X is H, F, Cl, Br or C 1-4 alkyl and n is 0 or 1, and their acid addition salts, are prepared by reaction of a phenyl Grignard reagent of formula wherein X is as defined and Hal is halogen, with a compound of formula wherein R is C 1-4 alkyl and n is 0 or 1, in an anhydrous solvent system, decomposing the reaction mixture with an acid to obtain the acid addition salt of the desired base, and then obtaining the free base therefrom. Many saltforming acids are specified, and include penicillins, especially benzyl penicillin. Compounds of the last formula given above, wherein R is methyl, ethyl, butyl or isopropyl and n is 0 or 1 are prepared by reaction of the corresponding azabicyclo-octane or -nonane with the appropriate lower alkyl methacrylate, and are isolated via their acid addition salts. |
| priorityDate | 1965-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.